摘要
Objective To assess cognitive impairment and its correlation with power of quantitative electroencephalogram(qEEG)in patients with temporal lobe epilepsy(TLE).Methods Fifty-five patients with TLE seen consecutively in Suqian First Hospital and 40 healthy controls(HC)were assessed by Mini-Mental State Examination(MMSE),Brief Cognitive Battery(BCB)and qEEG.The global interhemispheric and intrahemispheric difference values for power spectral ratios(Dv-PSR)were calculated.Cognitive functions and Dv-PSR of the TLE patients and the HC were compared,and correlation between cognitive impairment and power of qEEG was assessed using Spearman correlation analysis.The significance level was set at P≤0.05.Results Statistical analysis showed that MMSE scores did not have statistically significant difference between the TLE patients and the HC(26.9±2.4 vs 27.3±2.6,t=0.502,P=0.549).However,BCB examination showed that immediate memory,incidental memory,delayed recall,learning test,verbal fluency and recognition differed significantly between the TLE and the HC groups(7.34±1.33 vs 8.92±1.37,6.05±1.12 vs 7.93±1.20,6.77±1.08 vs 8.19±1.14,11.87±4.47 vs 16.8±4.56,8.52±1.74 vs 9.75±1.36,8.74±1.19 vs 9.87±1.18,respectively;t=2.916,Z=3.204,t=2.549,Z=3.937,t=1.341,t=2.791,P<0.05).Interhemispheric Dv-PSR in frontal,central,temporal and parietal area was higher in the TLE group than in the HC group(0.478±0.043 vs 0.252±0.028,0.441±0.051 vs 0.306±0.039,0.394±0.027 vs 0.247±0.018,0.511±0.036 vs 0.224±0.021,respectively;t=3.711,2.403,3.144,4.327,P<0.05),and intrahemispheric Dv-PSR in frontal,central,parietal and occipital area(minus temporal area respectively)was also higher in the TLE group than in the HC group(0.521±0.024 vs 0.221±0.017,0.249±0.012 vs 0.167±0.008,0.187±0.013 vs 0.104±0.007,0.313±0.021 vs 0.127±0.009,respectively;t=4.208,3.192,2.611,3.737,P<0.05).Spearman analysis showed positive correlations between intrahemispheric,interhemispheric Dv-PSR and several cognitive domains impairment assessed by BCB(P<0.05).Conclusion There was mild cognitive impairment in TLE patients,which was significantly associated with Dv-PSR assessed by qEEG,suggesting that Dv-PSR measurement may be used as a marker for cognitive impairment in epilepsy.
