桂哌齐特联合尼麦角林治疗血管性痴呆临床观察

Clinical observation of Cinepazide combined with Nicergoline in the treatment of vascular dementia

目的研究马来酸桂哌齐特联合尼麦角林治疗血管性痴呆的临床效果。方法将2015年1月1日-2017年12月31日天津市东丽区东丽医院收治的血管性痴呆患者60例随机分为对照组和观察组各30例。对照组患者给予常规治疗,观察组患者在对照组治疗基础上,加用马来酸桂哌齐特静脉点滴及尼麦角林口服,比较两组治疗前及治疗6个月后MMSE量表评分。结果治疗6个月后,两组MMSE评分均高于治疗前,且观察组MMSE评分高于对照组,差异均有统计学意义(P<0.01)。结论在常规治疗基础上加用马来酸桂哌齐特静脉点滴及尼麦角林口服可较常规治疗明显改善血管性痴呆患者的认知功能,值得大家借鉴。

Objective To study the clinical efficacy of Cinepazide Maleate combined with Nicergoline in the treatment of vascular dementia by statistical analysis. Methods From January 1,2015 to December 31,2017,60 patients with vascular dementia admitted to Dongli Hospital,Dongli District,Tianjin were randomly divided into control group and observation group with 30 cases in each group. Patients in the control group were given routine treatment,while patients in the observation group were given Cinepazide Maleate intravenous drip and Nicergoline orally on the basis of the treatment in the control group. All patients were given MMSE scale score before treatment and 6 months after treatment. Results After 6 months of treatment,the MMSE scores of the two groups were higher than those before treatment,and the MMSE scores of the observation group were higher than that of the control group,the differences were statistically significant(P <0.01). Conclusion Cinepazide maleate intravenous drip and nicergoline orally could significantly improve the cognitive function of vascular dementia patients on the basis of routine treatment,which was worth learning from.