天麻素注射液联合盐酸氟桂利嗪治疗偏头痛的效果观察

The effects of Gastrodin injection combined with flunarizine hydrochloride on migraine

目的探讨天麻素注射液与盐酸氟桂利嗪胶囊联合治疗偏头痛的效果。方法随机选取本院收治的180例偏头痛患者,并按照治疗方法不同分为对照组与观察组,各90例;对照组采用盐酸氟桂利嗪胶囊治疗,每晚睡前服用,10 mg/次,1次/d;观察组于对照组治疗基础上采用天麻素注射液治疗, 1次/d;分别于治疗前、治疗10、20、30 d后采用视觉模拟评分法评价疼痛状况;记录2组治疗前、治疗30 d后发病持续时间和发病次数;检测2组患者治疗前、治疗30 d后血浆5-HT水平;采用世界卫生组织生存质量评分表(WHOQOL-100)评估患者治疗前、治疗30 d后生活质量,评价2组治疗效果,并记录治疗期间出现的不良反应。结果随着治疗时间的延长,患者VAS评分较治疗前明显下降,且观察组治疗10、20、30 d后VAS评分明显低于对照组(P<0.05);2组患者治疗30 d后发病持续时间较治疗前明显缩短,发病次数较治疗前明显减少,而观察组治疗30 d后发病持续时间和发病次数明显少于对照组(P<0.05);2组患者治疗30 d后血浆5-HT水平较治疗前明显下降,观察组治疗30 d后血浆5-HT水平下降程度较对照组显著(P<0.05);2组患者治疗30 d后生活质量评分较治疗前明显升高,观察组治疗30 d后生活质量评分升高程度优于对照组(P<0.05);观察组治疗总有效率为95.56%(86/90),明显高于对照组84.44%(76/90)(P<0.05);观察组治疗期间不良反应率为3.33%(3/90)与对照组2.22%(2/90)比较无明显差异(P>0.05)。结论天麻素注射液与盐酸氟桂利嗪胶囊治疗偏头痛可显著降低血浆5-HT水平,缓解患者疼痛,缩短发病时间和发病次数,从而改善患者生活质量,且联合用药不良反应并未明显增加,因此具有一定安全性。

Objective To investigate the effects of gastrodin injection combined with flunarizine hydrochloride capsule on migraine.Methods 180 migraine patients admitted to the hospital were randomly divided into the control group and the observation group according to different treatment methods,90 cases each.The control group was treated with flunarizine hydrochloride capsules,taken every night before bedtime,10 mg/time,once a day.The observation group was treated with gastrodin injection once a day on the basis of the control group.Pain status was evaluated by visual analogue scale before treatment,at 10th,20thand 30th d after treatment,respectively.The duration and incidence of the disease were recorded before and after treatment.Plasma 5-HT levels were measured before and at 30th d after treatment.The World Health Organization Quality of Life Score(WHOQOL-100)was used to assess the quality of life were recorded during treatment.Results With the prolongation of treatment time,the VAS score of patients was significantly lower than that before treatment,and the VAS scores of the observation group were significantly lower than those of the control group at at 10th,20thand 30th d after treatment(P<0.05).The duration of onset in both groups was significantly shorter at 30th d after treatment than that before treatment,and the number of cases was significantly lower at 30th d after treatment than that before treatment,while the duration of onset and incidence of the observation group were significantly less than those of the control group(P<0.05).The levels of plasma 5-HT in the two groups were significantly lower at 30th d after treatment than those before treatment.The decrease of plasma 5-HT level in the observation group was significantly higher than that in the control group(P<0.05).The quality of life scores of the two groups were significantly higher at 30th d after treatment than that before treatment.The quality of life scores of the observation group were higher than that of the control group(P<0.05).The total effective rate of the observation group was 95.56%(86/90),which was significantly higher than that of the control group(84.44%(76/90)(P<0.05).The adverse reaction rate of two groups during the treatment was not significant difference[3.33%(3/90)vs 2.22%(2/90)](P>0.05).Conclusion The treatment of migraine with gastrodin injection and flunarizine hydrochloride capsule could significantly reduce plasma 5-HT level,relieve pain,shorten the onset time and number of cases,thus improve the quality of life of patients,and the adverse drug reaction had not increased significantly.Therefore,it had certain security.