注射用丹参多酚酸对脑卒中患者的疗效及血流变、肢体与神经功能的影响

Influence of Salvianolic Acids for Injection on hemorrheology,limb and nerve function in stroke patients

目的 探讨注射用丹参多酚酸对脑卒中患者血流变、肢体与神经功能的影响.方法 选取唐山市人民医院2017年2月-2019年2月诊治的脑卒中患者146例,采用随机数字表法分为两组(各73例),对照组患者实施常规治疗,观察者患者常规治疗基础上联用注射用丹参多酚酸0.13 g/d静脉滴注,均连续治疗14d.于治疗前后行血流变、生化指标检测,并行肢体与神经功能评价,比较两组患者的治疗效果及安全性.结果 两组患者治疗后全血高切黏度、全血低切黏度、血浆黏度、血小板聚集率、C反应蛋白、D-二聚体、同型半胱氨酸(Hcy)、神经元特异性烯醇化酶(NSE)、美国国立卫生研究院卒中量表(NHISS)评分较治疗前显著降低(P<0.05),简式运动功能量表(FMA)、日常生活能力(ADL)评分较治疗前显著增加(P<0.05).观察组患者治疗后全血高切黏度、全血低切黏度、血浆黏度、血小板聚集率、C反应蛋白、D-二聚体、Hcy、NSE、NHISS评分低于对照组(P<0.05),FMA评分、ADL评分高于对照组(P<0.05);观察组患者总有效率高于对照组(P<0.05).两组患者不良反应(心率异常、血压异常、肝肾功能损害)比较,差异无统计学意义.结论 注射用丹参多酚酸可改善脑卒中患者的血流变状况,并提高患者的肢体与神经功能.

Objective To investigate the influence of Salvianolic Acids for Injection(SAFI) on hemorrheology,limb and nerve function in stroke patients.Methods 146 stroke patients were selected in Tangshan People’s Hospital from December 2016 to December 2018,who were divided into two groups by random number table method.73 patients received routine treatment as control group,and 73 patients combined with SAFI(0.13 g/d intravenous drip for 14 days) as observation group.Hemorrheology and biochemical indexes were measured before and after treatment.While parallel limb and nerve function were evaluated.Treatment effect and safety were compared between two groups.Results Whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity,platelet aggregation rate,C-reactive protein,D-dimer,homocysteine,neuron-specific enolase,and NHISS score were decreased significantly in two groups after treatment(P<0.05).FMA score and ADL score were increased significantly in two groups after treatment(P<0.05).Whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity,platelet aggregation rate,C-reactive protein,D-dimer,homocysteine,neuron-specific enolase,and NHISS score in observation group were lower than control group after treatment(P<0.05).FMA score and ADL score in observation group were higher than control group after treatment(P<0.05).Total effective rate in observation group was higher than control group(P<0.05).There were no significant differences in adverse reactions(heart rate abnormality,blood pressure abnormality,liver and kidney dysfunction) between two groups.Conclusion SAFI can improve hemorheological status in stroke patients,which can also improve limb and nerve function.