选择性剪接多聚嘧啶结合蛋白及其同源蛋白与恶性肿瘤相关性的研究进展

Research progress of relationship between alternative splicing PTB and its homologous proteins and malignant tumors

选择性剪接(alternative splicing)是指一个前体mRNA通过选择不同的剪接位点产生多个可编码功能相似或相反的mRNA剪接异构体的过程。多聚嘧啶结合蛋白(polypyrimidine tract-binding protein,PTB)是一种剪接调控因子,通过结合新生mRNA而抑制剪接发生。有关研究提示PTB及其同源蛋白剪接调控功能出现异常时可以导致肿瘤的发生。综述PTB及其同源蛋白与恶性肿瘤相关性的研究进展,有可能为肿瘤治疗提供新的选择,为未来靶点治疗提供新的思路。

Alternative splicing is a process that the pre-mRNA selects different splice sites to produce multiple mRNA splicing isomers with similar or opposite coding functions.Polypyrimidine tract-binding protein(PTB)is a splicing regulator that inhibits splicing by binding to nascent mRNA.Studies suggest that abnormalities in the splicing regulatory function of PTB and its homologous proteins can lead to tumorigenesis.This article reviews the research progress of the correlation between PTB and its homologous proteins and malignant tumors,which may provide new options for tumor treatment and new ideas for target therapy in the future.