摘要
目的探讨低密度脂蛋白受体(LDL-R)基因对第8外显子中的1063A/C多态与遵义人群高三酰甘油血症(HTG)的相关性。方法2014年3-8月采用聚合酶链反应产物直接测序分析99例HTG患者和162例健康对照者LDL-R基因1063A/C位点多态性。结果2组研究对象LDL-R基因1063A/C位点基因型频率和等位基因比较,差异均无统计学意义(P>0.05);HTG组AA基因型患者高密度脂蛋白胆固醇(HDL-C)、总胆固醇/HDL-C和低密度脂蛋白胆固醇/HDL-C水平与CC基因型比较,差异均有统计学意义(P<0.05)。结论LDL-R基因1063A/C位点多态与遵义汉族人群HTG发病无关,但LDL-R基因1063C等位基因可影响血液总胆固醇和低密度脂蛋白胆固醇水平。
Objective To investigate correlation between low density lipoprotein receptor(LDL-R)gene 1063A/C polymorphism with hypertriglyceridemia of the crowds in Zunyi population.Methods 1063A/C polymorphism of 99 hypertriglyceridemia patients and 162 healthy individuals were tested by sequencing after polymerase chain reaction.Results There was no significant difference in genotype frequency and allele frequency of 1063A/C locus in LDL-R between the two groups(P>0.05),but there was significant difference in the level of high density lipoprotein cholesterol(HDL-C)、TC/HDL-C and LDL-C/HDL-C between AA and CC genotype in HTG group(P<0.05).Conclusion There is no correlation between the 1063A/C polymorphism of LDL-R gene and the incidence of HTG in Han nationality of Zunyi population.However,the allele of LDL-R gene can affect total cholesterol(TC)and LDL-C levels in the blood.
作者
罗莉
韦鑫佩
张志敏
杨明理
肖代敏
王博浯
赵毅
LUO Li;WEI Xinpei;ZHANG Zhimin;YANG Mingli;XIAO Daimin;WANG Boyu;ZHAO Yi(Zuyi Medical University,Zuiyi,Guizhou 563099,China;Department of Clinical Laboratory,Affiliated Hospital of Zunyi Medical College,Zuiyi,Guizhou 563000,China)
出处
《现代医药卫生》
2019年第22期3429-3432,共4页
Journal of Modern Medicine & Health
基金
贵州省科技厅医学科研项目(黔科合J字LKZ〔2012〕39号)
国家级大学生创新创业训练计划项目(201710661010)
贵州省大学生创新创业训练计划项目(201710661010)
遵义医学院大学生创新创业训练计划项目(遵医20163708、遵医科院20162316、遵医科院20173810,遵医科院20173831)