摘要
UNC-51样激酶1(ULK1)作为一种丝氨酸/苏氨酸激酶是哺乳动物中的自噬启动因子,也是酵母中Atg1的同源蛋白.近年来,大量研究揭示了ULK1的结构特征及其生物学功能,并阐明了其调控自噬的途径及其与多种疾病的关系.最新研究还发现了一系列直接或间接靶向ULK1调节自噬的小分子化合物,为开发靶向自噬的新候选药物提供了线索.该文综述了ULK1作为自噬启动因子的复杂生物学功能、与多种疾病的关系及其潜在的靶向治疗应用.
UNC-51-like kinase 1(ULK1),the yeast Atg1 ortholog,is well-known to be the serine/threonine kinase and the autophagic initiator in mammals.Recently,extensive studies have illustrated the partial structure characteristics and the biological function of ULK1,as well as its regulatory autophagic pathways and relationships with diverse diseases.More interestingly,some small-molecule compounds have been reported to directly or indirectly target ULK1-modulating autophagy,thereby providing some clues on exploiting novel candidate drugs that target autophagy.In this review,we discuss the complicated biological function of ULK1 and its associations with human diseases,as well as its potential targeted therapeutic applications.
作者
张岚
欧阳亮
刘博
ZHANG Lan;OUYANG Liang;LIU Bo(School of Life Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China;State Key Laboratory of Biotherapy,Sichuan University,Chengdu 610041,China)
出处
《厦门大学学报(自然科学版)》
CAS
CSCD
北大核心
2019年第6期787-801,共15页
Journal of Xiamen University:Natural Science
基金
国家自然科学基金(81673455,81673290)
国家自然科学基金青年基金(81602953)