彩色多普勒超声诊断新生儿甲状腺功能减低症的价值分析

Analysis on Value of Color Doppler Ultrasound in the Diagnosis of Congenital Hypothyroidism

目的分析彩色多普勒超声诊断新生儿甲状腺功能减低症(CH)的应用价值。方法选取我院新生儿筛查中心实验室2018年1月至2018年12月确诊的130例CH患儿,分析其彩色多普勒超声特征,评估其在筛查CH中的价值。结果彩色多普勒超声检查显示,130例CH患儿中甲状腺体积增大75例、体积正常24例、甲状腺缺如或异位8例。CH患儿甲状腺上动脉血流速度高于正常新生儿(P <0.05)。CH患儿甲状腺左右叶左右径、前后径及峡部前后径均长于正常新生儿(P <0.05)。甲状腺缺如或异位CH患儿的血清TSH水平显著高于体积增大、缩小或正常患儿(P <0.05), FT4水平显著高于体积正常患儿及体积缩小患儿(P <0.05), FT3水平显著高于体积增大患儿及体积正常患儿(P <0.05)。结论彩色多普勒超声能有效评估新生儿甲状腺腺体大小、形态及位置,观察腺体内部回声及血流动力学情况,在筛查CH中具有较高的应用价值。

Objective To analyze the application value of color Doppler ultrasound in the diagnosis of congenital hypothyroidism(CH). Methods 130 cases of CH children diagnosed in our neonatal screening center laboratory from January 2018 to December 2018 were selected. The features of color Doppler ultrasound were analyzed, and the value in CH screening was evaluated. Results Color Doppler ultrasound showed 75 cases of increased thyroid volume, 24 cases of normal volume and 8 cases of absent or ectopic thyroid among 130 CH children. The blood flow velocity of thyroid superior arteries in CH children was higher than that in normal neonates(P <0.05). The left and right diameters and anteroposterior diameter of left and right thyroid lobes, and the anteroposterior diameter of isthmus in CH children were longer than those of normal neonates(P <0.05). The serum TSH level in CH children with absent or ectopic thyroid was significantly higher than that in children with increased, decreased or normal thyroid volume, the FT4 level was significantly higher than that in children with normal or decreased thyroid volume, and the FT3 level was significantly higher than that in children with increased or normal thyroid volume(all P <0.05). Conclusions Color Doppler ultrasound can effectively evaluate the size, shape and location of neonatal thyroid gland, and observe the internal echo and hemodynamics of gland, which has higher application value in the CH screening.