己酮可可碱治疗男性少弱畸形精子症的临床研究

Clinical Study on Pentoxifylline in the Treatment of Male Oligoasthenospermia

目的研究采用己酮可可碱治疗男性少弱畸形精子症患者的临床效果。方法选取2015年6月至2016年2月期间我院生殖医学中心收治的男性少弱畸形精子症患者71例,均采用己酮可可碱口服治疗,对比分析患者治疗前后的精液常规结果,分析己酮可可碱治疗男性少弱畸形精子症的临床效果。结果治疗后,71例患者的PR、正常形态、前向运动精子总数及精子存活率明显优于治疗前,差异均有统计学意义(P <0.05)。71例患者治疗前后的精液浓度、精液量、 NP比较,差异无统计学意义(P>0.05)。结论己酮可可碱可明显改善少弱畸形精子症患者的精子活力、存活率及形态,增加前向运动精子数,提高其生活质量和家庭幸福指数。

Objective To study the clinical effect of pentoxifylline in the treatment of male patients with oligoasthenospermia.Methods 71 male patients with oligoasthenospermia admitted to our reproductive medicine center from June 2015 to February 2016 were selected and given pentoxifylline orally. The semen routine results before and after treatment were compared and analyzed. The clinical effect of pentoxifylline in the treatment of oligoasthenospermia was analyzed. Results After treatment, the PR, normal morphology, total number of forward motility sperm and sperm survival rate of sperm in 71 patients were significantly better than those before treatment, with statistical differences(P <0.05). No statistical difference was found in the semen concentration, semen quantity and NP of 71 patients before and after treatment(P >0.05). Conclusions Pentoxifylline can significantly improve the sperm motility, survival rate and morphology of oligoasthenospermia patients, increase the number of forward motile sperm, improve the quality of life and family happiness index.