重症监护病房脓毒症患儿预后及其影响因素分析

Analysis on Prognosis of Children with Sepsis in Intensive Care Unit and the Influencing Factors

目的探讨重症监护病房脓毒症患儿预后及其影响因素。方法回顾性分析我院2010年5月至2018年5月重症监护病房收治的124例脓毒症患儿,根据其预后是否死亡分为病死组(8例)与存活组(116例),收集患儿的资料,对基础疾病、并发症及治疗措施等方面的变量进行单因素分析,并采用Logistic回归方程作多因素分析,探讨重症监护病房脓毒症患儿预后及其影响因素。结果病死组的血小板计数、血清白蛋白水平、 PCIS显著低于存活组(P <0.05)。病死组的尿路感染发生率、 MODS受累脏器、机械通气时间及PCT、 WBC水平显著高于存活组(P <0.05)。Logistic回归分析结果显示,血小板计数、 PCIS、尿路感染、 MODS受累脏器、机械通气时间、血清白蛋白、 PCT、 WBC与脓毒症患儿病死存在密切联系(P <0.05)。结论临床应尽早全面掌握重症监护病房脓毒症患儿的情况,避免血小板计数、尿路感染、 MODS受累脏器、机械通气时间、血清白蛋白、PCT、 WBC等因素对患儿造成危害。

Objective To explore the prognosis of sepsis children in intensive care unit and the influencing factors. Methods 124 children with sepsis admitted to our intensive care unit were retrospectively analyzed and divided into death group(8 cases) and survival group(116 cases) according to the prognosis. Univariate analysis was carried out on variables of basic diseases, complications and treatment measures. Multivariate analysis was carried out by Logistic regression equation, to investigate the prognosis of sepsis children in intensive care unit and the influencing factors. Results The platelet count, serum albumin level and PCIS of the death group were significantly lower than those of the survival group(P <0.05). The incidence of urinary tract infection, MODS involved organs, mechanical ventilation time, and PCT and WBC levels of the death group were significantly higher than those of the survival group(P <0.05). Logistic regression results showed that the platelet count, PCIS, urinary tract infection, MODS involved organs, mechanical ventilation time, serum albumin, PCT and WBC were closely related to the death of sepsis children(P <0.05). Conclusions The clinical situation of the children with sepsis in intensive care unit should be fully grasped as soon as possible to avoid the harm of platelet count, urinary tract infection, MODS involved organs, mechanical ventilation time, serum albumin, PCT, WBC and other factors.