吸入用沙丁胺醇联合布地奈德对COPD急性加重期的作用

Effect of Inhaled Salbutamol Combined with Budesonide on Acute Exacerbation of COPD

目的观察吸入用沙丁胺醇联合布地奈德对COPD急性加重期的作用。方法选取2015年1月~2017年1月我院治疗的86例COPD急性加重期患者,随机分为观察组和对照组,每组43例。对照组在常规治疗的基础上雾化吸入布地奈德,观察组在对照组的基础上吸入用沙丁胺醇。比较两组治疗前后用力肺活量(FVC)、第1秒用力呼气容积(FEV1),临床治疗效果。结果治疗后,两组FVC、FEV1均高于治疗前,观察组FVC、FEV1分别为(2.08±0.57)L、(1.97±0.43)L,高于对照组的(1.69±0.49)L、(1.47±0.36)L,差异有统计学意义(P<0.05);观察组治疗有效率为97.67%,高于对照组的76.74%,差异有统计学意义(P<0.05)。结论吸入用沙丁胺醇联合布地奈德有助于改善COPD急性期患者FVC、FEV1,具有较高的疗效。

Objective To observe the effect of inhaled salbutamol combined with budesonide on acute exacerbation of COPD.Methods 86 patients with acute exacerbation of COPD who were admitted to hospital from January 2015 to January 2017 were randomly divided into observation group and control group,with 43 cases in each group.The control group was inhaled budesonide on the basis of conventional treatment,and the observation group inhaled salbutamol on the basis of the control group.The forced vital capacity(FVC)and the forced expiratory volume in the first second(FEV1)before and after treatment were compared between the two groups.Results After treatment,FVC and FEV1 were higher than those before treatment.The FVC and FEV1 of the observation group were(2.08±0.57)L and(1.97±0.43)L,respectively,which was higher than that of the control group(1.69±0.49)L,(1.47±0.36)L,the difference also had statistical significance(P<0.05);the effective rate of observation group was 97.67%,which was higher than 76.74%of the control group,the difference was statistically significant(P<0.05).Conclusion Salbutamol inhalation combined with budesonide can improve the FVC and FEV1 in patients with acute COPD and improve the curative effect.It is worthy of application.