参芪地黄汤治疗早期糖尿病肾病的疗效

Effect of Shenqi Dihuang Decoction in Treating Early Diabetic Nephropathy

目的观察参芪地黄汤治疗早期糖尿病肾病的疗效。方法选择2018年1月~12月我院收治的早期糖尿病肾病患者60例,按照随机数字表法分为治疗组和对照组,每组30例。两组均进行基础降糖降压治疗,对照组予缬沙坦治疗,治疗组在对照组治疗基础上加用参芪地黄汤治疗,比较两组治疗前后中医临床证候积分、肌酐(Scr)、尿素氮(BUN)、胱抑素C(Cys-C)、24h尿蛋白定量、临床疗效及安全性情况。结果治疗后,两组中医临床证候积分较治疗前降低,治疗组中医临床证候积分低于对照组,差异有统计学意义(P<0.05)。两组Scr、BUN、24h尿蛋白定量、Cys-C较治疗前降低,治疗组Scr、BUN、24h尿蛋白定量、Cys-C低于对照组,差异有统计学意义(P<0.05)。治疗组总有效率为86.67%,高于对照组的63.33%,差异有统计学意义(P<0.05)。结论参芪地黄汤联合缬沙坦相比单用缬沙坦能更有效降低早期糖尿病肾病患者Scr、BUN、Cys-C水平,减少24h尿蛋白定量,降低中医临床证候积分,改善临床症状,疗效确切。

Objective To observe the efficacy of Shenqi Dihuang Decoction in the treatment of early diabetic nephropathy.Methods 60 patients with early diabetic nephropathy admitted to our hospital from January to December 2018 were enrolled.The patients were divided into treatment group and control group according to the random number table method,30 cases in each group.The two groups were treated with basal hypoglycemic and hypotensive treatment.The control group was treated with valsartan.The treatment group was treated with Shenqi Dihuang Decoction on the basis of the control group.The TCM clinical syndrome scores and serum creatinine(Scr)were compared before and after treatment,urea nitrogen(BUN),cystatin C(Cys-C),24h urine protein quantification,clinical efficacy and safety.Results After treatment,the scores of TCM clinical syndromes in the two groups were lower than those before treatment.The scores of TCM clinical syndromes in the treatment group were lower than those in the control group,the difference was statistically significant(P<0.05).The Scr,BUN,24h urine protein and Cys-C were lower than those before treatment.The Scr,BUN,24h urine protein and Cys-C in the treatment group were lower than the control group,the difference was statistically significant(P<0.05).The total effective rate of the treatment group was 86.67%,which was higher than that of the control group 63.33%,the difference was statistically significant(P<0.05).Conclusion Shenqi Dihuang Decoction combined with valsartan can effectively reduce the levels of Scr,BUN and Cys-C in patients with early diabetic nephropathy,reduce the quantification of 24h urine protein,reduce the clinical syndrome score of TCM,and improve clinical symptoms.The effect is exact.