通淋固本汤联合体外冲击波治疗输尿管上段结石的疗效

Efficacy of Tonglin Guben Decoction Combined with Extracorporeal Shock Wave in the Treatment of Upper Ureteral Calculi

目的探讨通淋固本汤联合体外冲击波治疗输尿管上段结石的疗效。方法选取2017年1月~2018年12月我院收治的输尿管上段结石患者40例作为研究对象,按照随机数字表法将其分为对照组和观察组,每组20例。对照组给予体外冲击波治疗,观察组在对照组基础上联合通淋固本汤治疗,比较两组临床疗效、治疗前后生化指标[血肌酐(Scr)、半胱氨酸蛋白酶抑制剂C(Cys-C)、中性粒细胞明胶酶相关载脂蛋白(NGAL)]及结石清除率。结果观察组总有效率为95.00%,高于对照组的65.00%,差异有统计学意义(P<0.05);治疗后,两组Scr低于治疗前,Cys-C、NGAL高于治疗前,且观察组Scr、Cys-C、NGAL优于对照组,差异有统计学意义(P<0.05);观察组结石清除率为95.00%,高于对照组的65.00%,差异有统计学意义(P<0.05)。结论通淋固本汤联合体外冲击波治疗输尿管上段结石可有效提高结石清除率,减低肾损伤,提高临床治疗效果。

Objective To investigate the efficacy of Tonglin Guben Decoction combined with extracorporeal shock wave in the treatment of upper ureteral calculi.Methods A total of 40 patients with upper ureteral calculi admitted to our hospital from January 2017 to December 2018 were enrolled.The patients were divided into control group and observation group according to the random number table method,20 cases in each group.The control group was treated with extracorporeal shock wave therapy.The observation group was treated with Tonglin Guben Decoction on the basis of the control group.The clinical efficacy and biochemical parameters before and after treatment were compared.[Serum creatinine(Scr),cysteine protease inhibitor C(Cys-C),neutrophil gelatinase-associated apolipoprotein(NGAL)]and stone clearance.Results The total effective rate of the observation group was 95.00%,which was higher than that of the control group 65.00%,the difference was statistically significant(P<0.05).After treatment,the Scr of the two groups was lower than that before treatment,and Cys-C and NGAL were higher than before treatment.The Scr,Cys-C and NGAL in the observation group were better than the control group,the difference was statistically significant(P<0.05).The stone removal rate in the observation group was 95.00%,which was higher than that in the control group 65.00%,the difference was statistically significant(P<0.05).Conclusion Tonglin Guben Decoction combined with extracorporeal shock wave treatment of upper ureteral calculi can effectively improve the clearance rate of stones,reduce renal damage and improve the clinical treatment effect.