二甲双胍对骨代谢的影响

Effects of metformin on bone metabolism

二甲双胍(metformin,MF)作为一种抗糖尿病药物,在世界范围内被广泛用于治疗2型糖尿病(type 2 diabetes mellitus,T2MD)。近年来,二甲双胍在骨代谢中的作用逐渐得到证实,大量体内外实验表明其对成骨细胞、脂肪细胞等细胞的代谢产生一定影响。已经证实二甲双胍通过激活腺苷酸活化蛋白激酶(adenosine monophosphate activated protein kinase,AMPK)途径促进成骨细胞的分化、矿化以及成骨相关基因的表达。一些临床研究显示,二甲双胍对于糖尿病性骨质疏松(DM-induced bone fragility)产生有益的作用。本文对相关文献加以综述,为二甲双胍在成骨方面的临床研究和应用提供依据和思路。

Metformin is an antidiabetic drug,widely used in the treatment of type 2 diabetes mellitus(T2DM).In recent years,the role of metformin in bone remodeling has been gradually confirmed.A large number of in vitro and in vivo experiments have shown that it has an effect on the metabolism of cells such as osteoblasts and adipocytes.Metformin has been shown to promote osteoblast differentiation,mineralization,and bone formation-related gene expression by activating adenosine monophosphate activated protein kinase(AMPK)signaling pathway.Some clinical studies have shown that metformin has a beneficial effect on bone fragility in diabetic patients.This article reviews the relevant literature and provides the basis for the clinical research and application of metformin in osteogenesis.