粪便微生物移植研究现状及其在炎症性肠病中的应用

Current status of fecal microbial transplantation and its application in inflammatory bowel disease

炎症性肠病(IBD)是免疫相关性肠道炎性反应性疾病,包括溃疡性结肠炎(UC)和克罗恩病(CD),发病机制复杂,涉及环境、生活方式、饮食、遗传、肠道菌群等多种致病相关因素,尽管IBD是多种因素介导的疾病,但越来越多的证据表明肠道菌群紊乱被认为是IBD发病的重要因素。因此恢复健康肠道菌群对治疗IBD有重要意义。近年来多项研究表明粪菌移植(fecal microbial transplantation,FMT)似乎非常有希望治疗或诱导IBD症状的缓解。本文就FMT的研究现状及其在IBD治疗中的应用作一综述。

Inflammatory bowel disease(IBD)is an immune-related intestinal inflammatory disease,Includes ulcerative colitis(UC)and Crohn's disease(CD),The pathogenesis is complex,involving various pathogenic factors such as environment,lifestyle,diet,genetics,and intestinal flora.Although IBD is a multifactorially mediated disease,there are increasing evidences that intestinal flora disorders are considered to be important factors in the pathogenesis of IBD.Therefore,restoring healthy intestinal flora is important for the treatment of IBD.In recent years,several studies have shown that fecal microbial transplantation(FMT)appears to be very promising for the treatment or induction of remission of IBD symptoms.This article reviews the current research status of FMT and its application in the treatment of IBD.