脑栓通胶囊治疗急性脑梗死疗效的Meta分析

Efficacy of Naoshuantong Capsule in the Treatment of Acute Cerebral Infarction:a Meta-analysis

目的系统评价脑栓通胶囊治疗急性脑梗死的疗效。方法检索中文科技期刊全文数据库(VIP)、万方数据库、中国期刊全文数据库(CNKI)、中国生物医学文献系统(CMB)、MedLine、EMbase、PubMed数据库,收集脑栓通胶囊治疗脑梗死急性期或恢复期的随机对照试验(RCT),经过文献筛选和文献质量评价后,采用RevMan 5.3软件对纳入文献资料进行Meta分析。结果共纳入15项RCT研究,共1 619例病人,其中试验组809例,对照组810例。Meta分析结果显示,与对照组相比,脑栓通胶囊联合化学药物治疗组有效率升高[RR=1.23,95%CI(1.12,1.35),P<0.000 1];治疗前后中国卒中量表评分差值[MD=3.49,95%CI(2.18,4.81),P<0.000 01]、欧洲卒中量表评分[MD=12.12,95%CI(9.65,14.58),P<0.000 01]、Barthel指数[MD=7.77,95%CI(7.29,8.25),P<0.000 01]和改良Barthel指数[MD=11.41,95%CI(6.27,16.55),P<0.000 1]比较,差异均有统计学意义。结论脑栓通胶囊联合化学药物治疗急性脑梗死疗效明显优于单纯化学药物治疗。

Objective To systematically evaluate the efficacy of Naoshuantong capsule(NSTC) in the treatment of acute cerebral infarction(ACI).Methods The literatures were retrieved from VIP database,Wanfang database,China National Knowledge Infrastructure(CNKI),Chinese BioMedical database(CBM),MedLine,EMbase,PubMed.The randomized controlled trials(RCTs) about the efficacy of NSTC in the treatment of acute or convalescent cerebral infarction were collected.After literature screening and quality evaluation,the included literatures were analyzed with RevMan 5.3 software.Results A total of 1 619 patients were included in 15 RCTs,including 809 patients in the experimental group and 810 patients in the control group.Meta analysis results showed that compared with the control group,the effective rate in the treatment group of NSTC and chemical medicine was significantly increased [RR=1.23,95%CI(1.12,1.35),P<0.000 1].There were significant differences in the scores of Chinese Stroke Scale(CSS) [MD=3.49,95%CI(2.18,4.81),P<0.000 01],European Stroke Scale(ESS) [MD=12.12,95%CI(9.65,14.58),P<0.000 01],Barthel index [MD=7.77,95%CI(7.29,8.25),P<0.000 01],Modified Barthel Index(MBI) [MD=11.41,95%CI(6.27,16.55),P<0.000 01] before and after treatment.Conclusion The curative effect of NSTC and chemical medicine for ACI was significantly better than that of chemical medicine alone.