摘要
肝癌及肝硬化治疗选择有限。细胞治疗(免疫细胞、干细胞)通过主动地调节机体免疫可以明显提高治疗效果。同时,在选择不同的细胞治疗方式时,临床医生也应充分考虑细胞治疗所伴发的不良反应。现就细胞治疗在肝癌与肝硬化的临床试验研究中的进展,包括治疗机制、优缺点及限制性等进行综述。
The treatment options for liver cancer and liver cirrhosis are limited.Cell therapy(immune cells,stem cells)can significantly improve the therapeutic effect by actively regulating body's immunity.In addition,when choosing different methods of cell therapy,clinicians should also fully consider the adverse reactions associated with cell therapy.This article reviews the progress of cells therapy in clinical trials of liver cancer and liver cirrhosis,including therapeutic mechanism,advantages,disadvantages and limitations.
作者
刘凯
王立峰
王福生
施明
Liu Kai;Wang Lifeng;Wang Fusheng;Shi Ming(Peking University 302 Clinical Medical School,Beijing 100039,China;Treatment and Research Center for Infectious Diseases,the Fifth Medical Center of PLA General Hospital,Beijing 100039,China;National Clinical Research Center for Infections Diseases,Beijing 100039,China)
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2019年第11期822-826,共5页
Chinese Journal of Hepatology
基金
国家重点研发计划(2017YFA0105703)
国家自然科学基金创新群体项目(81721002)
国家自然科学基金(81571567)。
关键词
肝硬化
间充质干细胞
肝癌
细胞治疗
Liver cirrhosis
Mesenchymal stem cells
Liver cancer
Cell therapy
