慢性乙型肝炎HBV DNA阴转和HBsAg清除对肝细胞癌发生的影响

Effect of chronic hepatitis B virus DNA negative transformation and HBsAg clearance on the occurrence of hepatocellular carcinoma

有效抗病毒治疗获得HBV DNA阴转和HBsAg清除能够减少肝细胞癌(HCC)的发生,但仍有部分患者有罹患HCC的风险,故筛选出这部分高危人群进行密切监测,对于减少HCC的发生至关重要。现回顾HBV DNA阴转和HBsAg的清除对HCC的发生及其危险因素和风险预测模型,为慢性乙型病毒性肝炎患者HCC高危人群的筛查及随访管理提供依据。

Achieving HBV DNA negative transformation and HBsAg clearance with effective antiviral therapy can reduce the incidence of HCC,but some patients are still at risk of developing HCC.Therefore,screening high-risk patients for close monitoring is essential to reduce the incidence of HCC.This paper reviews the occurrence of HCC,risk factors and risk prediction models of HBV DNA negative transformation and HBsAg clearance,and provides a basis for screening and follow-up management of high-risk group of HCC with chronic hepatitis B.