吸入性麻醉药七氟烷红外光谱研究

Study on infrared spectrum of inhalational anesthetics-sevoflurane

采用3种红外(IR)光谱方法[包括透射IR光谱(T-IR光谱)、衰减全反射IR光谱(ATR-IR光谱)和漫反射IR光谱(DR-IR光谱)]开展了七氟烷的分子结构研究。实验发现:七氟烷的红外吸收模式主要包括CH2不对称伸缩振动模式(νas CH2-sevoflurane)、CH2称伸缩振动模式(νs CH2-sevoflurane)、CF3不对称伸缩振动模式(νas CF3-sevoflurane)、CF3对称伸缩振动模式(νs CF3-sevoflurane)和CF伸缩振动模式(νCF-sevoflurane)等;七氟烷T-IR光谱质量要优于相应的ATR-IR光谱和DR-IR光谱。本项研究拓展了IR光谱在重要的吸入性麻醉药(七氟烷)结构研究的应用研究范围。

The sevoflurane organic molecular structure was characterized by the infrared(IR)spectrum including transmission IR spectrum(T-IR spectrum),attenuated total reflection IR spectrum(ATR-IR spectrum)and diffuse reflectance IR spectrum(DR-IR pectrum).There were CH2asymmetry stretch vibration mode(νasCH2-sevoflurane),CH2symmetry stretch vibration mode(νsCH2-sevoflurane),CF3asymmetry stretch vibration mode(νasCF3-sevoflurane),CF3symmetry stretch vibration mode(νsCF3-sevoflurane)and C-F stretch vibration mode(νCF-sevoflurane).It is founded that the spectrum quality of T-IR spectrum is better than ATR-IR spectrum and DR-IR spectrum.It is paper demonstrated the key roles of IR spectrum in the analysis of structure of the important inhalational anesthetics(sevoflurane).