济南地区膳食摄入与代谢综合征各要素对高尿酸血症的影响因素分析

Analysis of the influencing factors of dietary intake and metabolic syndrome on hyperuricemia in Jinan area

目的探讨济南地区膳食习惯及代谢综合征各要素对高尿酸血症的影响,为高尿酸血症的预防控制提供科学指导。方法选择2017-02~2018-10于该院健康管理中心体检的济南市常住居民200例作为研究对象,其中高尿酸血症者100例作为病例组,体检正常者100名作为对照组。收集研究对象的基本信息、生活饮食习惯、身体测量和生化指标等资料,并进行统计分析。结果多元线性回归分析显示体质量指数(BMI)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、肌酐(Cre)是血清尿酸水平的正向影响因素,而高密度脂蛋白胆固醇(HDL-C)是血清尿酸水平的负向影响因素(P<0.05)。二分类Logistic回归分析显示,有吸烟史、经常饮用啤酒、经常食用动物内脏、经常饮用甜饮料是高尿酸血症发生的危险因素,而经常定时补充维生素C和经常食用粗粮是高尿酸血症发生的抑制因素(P<0.05)。结论高BMI水平、高血脂水平均与高血清尿酸水平有关联。减少饮酒,少食动物内脏类等富含嘌呤的食物,经常补充维生素C,多吃粗粮可以预防或者减少高尿酸血症的发生。

Objective To investigate the influences of dietary habits and various elements of metabolic syndrome on hyperuricemia in Jinan area,and to provide scientific guidance for prevention and control of hyperuricemia.Methods A total of 200 permanent residents of Jinan city were selected as the research subjects at the Health Management Center of the hospital from February 2017 to October 2018.Among them,100 cases of hyperuricemia were taken as case group,and 100 cases of healthy persons receiving physical examination as control group.The basic information,dietary habits,physical measurements and biochemical indicators of the subjects were collected and statistical analysis was conducted.Results Multiple linear regression analysis showed that body mass index(BMI),total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C)and creatinine(Cre)were the positive influencing factors of serum uric acid level(P<0.05),while high-density lipoprotein cholesterol(HDL-C)was the negative influencing factor(P<0.05).Binary Logistic regression analysis showed that smoking history,regular beer consumption,frequent consumption of animal internal organs,and frequent consumption of sweet drinks were the risk factors of hyperuricemia,while regular supplement of vitamin C and regular consumption of coarse grains were the inhibition factors of hyperuricemia(P<0.05).Conclusion High BMI and hyperlipidemia are correlated with high uric acid level.Reducing alcohol consumption,eating less animal organs and other foods rich in purine,adding regular vitamin C supplementation and eating more coarse grains can prevent or reduce the occurrence of hyperuricemia.