结直肠癌患者术后吻合口瘘发生的危险因素分析

Analysis of the risk factors causing anastomotic leakage in colorectal cancer patients after surgery

目的分析结直肠癌患者术后吻合口瘘发生的危险因素。方法对该院2006-01~2018-06行结直肠癌根治术治疗的459例患者临床资料进行回顾性分析,采用单因素和多因素Logisitc回归分析探讨术后吻合口瘘发生的危险因素。结果吻合口瘘发生率为9.80%(45/459)。多因素Logistic回归分析结果显示年龄(OR=2.815)、术前合并糖尿病(OR=4.872)、术前合并低蛋白血症(OR=3.258)、肿瘤距肛门缘距离(OR=4.153)是结直肠癌术后吻合口瘘发生的危险因素。结论年龄、术前合并糖尿病、术前合并低蛋白血症、肿瘤距肛门缘距离是结直肠癌术后吻合口瘘发生的危险因素,围术期应充分考虑这些因素的影响,并采取适当的预防措施。

Objective To analyze the risk factors causing anastomotic leakage in colorectal cancer patients after surgery.Methods The clinical data of 459 colorectal cancer patients who had radical resection of colorectal cancer in our hospital from January 2006 to June 2018 were retrospectively analyzed.Univariate analysis and multivariate Logistic regression analysis were performed to analyze the risk factors causing anastomotic leakage after surgery.Results The incidence of anastomotic leakage was 9.80%(45/459).Multivariate Logistic regression analysis showed that age(OR=2.815),preoperative concurrent diabetes(OR=4.872),preoperative concurrent hypoproteinemia(OR=3.258)and the distance of the tumors from the anal verge(OR=4.153)were the risk factors of anastomotic leakage occurrence in colorectal cancer patients after surgery.Conclusion Age,preoperative concurrent diabetes,preoperative concurrent hypoproteinemia and the distance of the tumors from the anal verge are the risk factors of anastomotic leakage occurrence after colorectal cancer surgery.The influence of these factors should be taken into careful consideration during the perioperative period,and the appropriate preventive measures should be taken actively.