血浆D-二聚体动态变化在急性脑梗死诊断中的应用价值研究

Research on the Application Value of Plasma D-dimer in the Diagnosis of Acute Cerebral Infarction

目的探讨急性脑梗死(ACI)患者发病过程中血浆D-dimer(D-二聚体)变化与其预后的关系。方法采用北京热景公司生产的MQ60检测99例ACI患者及30例正常对照者血浆D-dimer水平变化,分析其与梗死体积大小、病情程度及预后的相关性。结果ACI患者血浆D-dimer水平变化与病情及预后关系密切,其中大体积梗死组血浆D-dimer升高水平、持续时间、神经功能受损程度均高于中、小体积梗死组,差异有统计学意义(P<0.05),其预后也最差。结论ACI患者血浆D-dimer水平可作为判断病情及预后的客观指标,D-dimer越高,病程持续时间将越长,预后越差。

Objective To evaluate the relationship between the change in pathogenic course of plasma D-dimer and prognosis in patients with acute cerebral infarction(ACI).Methods Plasma D-dimer concentrations of 99 patients with ACI and 30 cases healthy persons were determined,and the relative among D-dimer concentrations and focus size and severity of infarction and prognosis was analyzed.Results There was obvious difference(P<0.05)between the level of D-dimer in patients with ACI and the control group,the larger the infarction size was,the higher the D-dimer was(P<0.05),D-dimer in severe group was higher than that in mild group(P<0.05),there was a negative correlation between plasma D-dimer and neurological functional recovery degree.Conclusion In patients with ACI,the higher the D-dimer is,the longer it lasts,the poorer prognosis is.