血清D-二聚体、CRP、Hcy联合检测对冠心病的临床诊断价值

Clinical diagnostic value of combined detection of serum D-Dimer,CRP and Hcy for coronary heart disease

目的探讨血清D-二聚体、C反应蛋白(C-Reactive Protein,CRP)、同型半胱氨酸(Homocysteine,Hcy)联合检测对冠心病的临床诊断价值。方法选择2018年1-5月本院收治的70例冠心病患者作为研究对象,纳入观察组;将同期来本院体检的70名健康志愿者纳入对照组,比较两组入选者血清D-二聚体、CRP、Hcy检测结果,计算D-二聚体、CRP、Hcy阳性率,进一步分析血清D-二聚体、CRP、Hcy检测诊断冠心病的灵敏度、特异度。结果观察组患者血清D-二聚体、CRP、Hcy检测结果均显著高于对照组,差异有统计学意义(P<0.05);观察组患者D-二聚体、CRP、Hcy阳性率显著高于对照组,差异有统计学意义(P<0.05);血清D-二聚体、CRP、Hcy联合检测诊断冠心病灵敏度和特异度均良好,显著高于单独检测或二联检测,差异有统计学意义(P<0.05)。结论血清D-二聚体、CRP、Hcy检测能够为冠心病的早期诊断提供可靠依据,三者联合能够有效提高灵敏度和特异度。

Objective To investigate the clinical value of combined detection of serum D-dimer,c-reactive protein(CRP)and homocysteine(Hcy)for coronary heart disease.Methods Seventy patients with coronary heart disease admitted to our hospital from January 2018 to May 2018 were enrolled in the observation group.70 healthy volunteers who were admitted to our hospital during the same period were included in the control group.The serum concentrations of body,CRP and Hcy were compared and used to calculate the positive rates of D-dimer,CRP and Hcy,and the sensitivity and specificity of serum D-dimer,CRP and Hcy in the diagnosis and treatment of coronary heart disease were further analyzed.Results The serum levels of D-dimer,CRP and Hcy in the observation group were significantly higher than those in the control group(P<0.05).The positive rates of D-dimer,CRP and Hcy were significantly higher in the observation group than those in the control group,there was a statistical difference(P<0.05).Both sensitivity and specificity of combined detection of serum D-dimer,CRP,and Hcy in the diagnosis of coronary heart disease were excellent,they were significantly higher than the single detection or the double combination detection,differences were statistically significant(P<0.05).Conclusions The detection of serum D-dimer,CRP and Hcy could provide a reliable basis for the early diagnosis of coronary heart disease.The combination of the three indicators could effectively improve the sensitivity and specificity.