口服普萘洛尔联合局部外用马来酸噻吗洛尔治疗婴幼儿颌面部混合性血管瘤的临床效果

Study of the therapeutic effect of oral propranolol combined with topical timolol maleate in the treatment of mixed maxillofacial hemangioma in infants

目的观察口服普萘洛尔与局部外用马来酸噻吗洛尔联合应用治疗婴幼儿颌面部混合性血管瘤的疗效,为临床治疗提供证据。方法选取婴幼儿颌面部混合性血管瘤97例,随机分成A、B2组,A组50例,以口服普萘洛尔联合局部外用马来酸噻吗洛尔进行治疗,B组47例,仅口服普萘洛尔治疗。治疗前后记录瘤体颜色、体积、质地的变化,并完善彩超检查。随访时间为1~12个月。比较2组的疗效差异、显效时间及不良反应的差异。结果A组有效率为92.0%(46/50),B组有效率为74.5%(35/47),差异具有统计学意义(P<0.05)。A组平均治疗时间为4.2个月,B组平均治疗时间为5.5个月,相较于B组,A组治疗显效时间较快,差异具有统计学意义(t=3.211,P<0.05)。2组均未见严重不良反应。结论口服普萘洛尔与局部外用马来酸噻吗洛尔联合应用治疗婴幼儿颌面部混合性血管瘤效果良好。

Objective To observe the treatment effect of oral propranolol combined with topical timolol maleate for infantile maxillofacial mixed hemangioma and provide evidence for clinical treatment.Methods Ninety-seven cases of infantile maxillofacial mixed hemangioma were enrolled.The cases were randomly divided into A and B groups:50 cases in group A were treated with oral propranolol combined with topical timolol maleate,and 47 cases in group B were treated with oral propranolol only.The changes in the color,volume,and texture of the tumors were recorded before and after treatment,and color ultrasonography of the lesion area was performed.The follow-up time was 1-12 months.The differences in the curative effect,effective time and adverse reaction between the two groups were compared.Results The effective rate of group A was 92.0%(46/50)and that of group B was 74.5%(35/47),with a statistical significance(P<0.05).The mean time of treatment in group A was 4.2 months and that in group B was 5.5 months.Compared with group B,the treatment time of group B was shorter(t=3.211,P<0.05),and no serious adverse reactions occurred in both groups.Conclusion Oral propranolol combined with topical timolol maleate is effective in the treatment of mixed hemangioma of the maxillofacial region in infants.