生物标记物在骨关节炎早期诊断中的应用分析

Analysis of bio-markers in osteoarthritis early diagnosis

通过分析总结多种生物标记物生物学特性,探索不同标记物用于骨关节炎早期诊断的可靠性。软骨寡聚基质蛋白、Ⅰ型胶原N端交联端肽及Ⅱ型胶原C端交联端肽可能是骨关节炎早期诊断的有效标记物,透明质酸与Ⅰ型胶原蛋白C端交联端肽更适用于评价骨关节炎的发生及发展,而长链非编码RNA与微小RNA对于骨关节炎的诊断及评估作用仍有待进一步研究。同一种标记物可能同时兼具2种或以上的功能,本研究旨在通过对现有生物标记物特点进行总结,寻找一种能稳定、精确反映早期骨关节退行性变的标记物。

Through analysis and summary of the biological characteristics of various biomarkers,to explore the reliability of different markers for early diagnosis of osteoarthritis.Cartilage oligomeric matrix protein,N-terminal crosslinked telopeptide of typeⅠcollagen and C-terminal crosslinked telopeptide of typeⅡcollagen are the possible effective markers in osteoarthritis early diagnosis.Hyaluronic acid and C-terminal crosslinked telopeptide of type I collagen are more suitable for evaluating the ollurrence and derelopment of osteoarthritis.The efficacy of miRNA and lncRNA in osteoarthritis diagnosis and evaluation remains to be proved.Each marker may has two or more biological effect,this paper will focus on finding out an accurate and stable marker with the analysis and summary of present bio-markers.