NB-UVB治疗早期蕈样肉芽肿的疗效及不良反应观察

Efficacy and Side Effects of NB-UVB in Treatment of Early Stage Mycosis Fungoides

目的评估窄谱中波紫外线(narrow band ultraviolet B, NB-UVB)治疗早期蕈样肉芽肿(early-stage mycosis fungoides, EMF)的安全性及有效性。方法回顾性分析2005年12月至2015年12月,EMF患者38例的临床资料,采用NB-UVB治疗,初始能量密度0. 2 J/cm2,每周3次,根据患者皮肤耐受程度对照射剂量进行调整,每周逐渐增加能量密度0. 2 J/cm2。治疗后1个月随访,记录患者的治疗效果和不良反应,并进行分析。结果 38例EMF中,完全缓解(complete response, CR)36例(94. 7%),部分缓解(partial response, PR)2例(5. 3%),有效率(CR+PR)为100%。NB-UVB治疗过程中出现的不良反应包括皮肤干燥36例、瘙痒19例、红斑3例、光化性黑子14例、色素沉着31例、色素脱失8例、甲改变2例、毛囊炎6例、眼结膜干燥6例、视物模糊11例、皮肤癌变0例。结论长期应用NB-UVB治疗早期蕈样肉芽肿临床疗效好、安全性高,不良反应少。

Objective To evaluate the efficacy and safety of narrow-band UVB(NB-UVB)in the treatment of early stage mycosis fungoides(EMF).Methods A retrospective study was performed on 38 patients of early-stage MF(EMF)treated with NB-UVB. The therapeuticefficacy and side effects of EMF were assessed.Results Among the 38 patients,36 patients(94. 7%)achieved complete response(CR),and 5 patients(5. 3%)partial response(PR). The adverse reactions to NB-UVB included dry skin(36 cases),pruritus(19 cases),erythema(3 cases),lentigo(14 cases),hyperpigmentation(31 cases),depigmentation(8 cases),nail changes(2 cases),folliculitis(6 cases),dry eyes(6 cases),blurred vision(11 case)and skin carcinogenesis(0 case).Conclusions Long-term NB-UVB treatment for EMF is effective and reliable with only a few adverse reactions.