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生物制剂在风湿病的应用 被引量:3

Application of Biological Agent in Rheumatism
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摘要 生物制剂是通过基因工程合成的具有免疫调节作用的蛋白质.根据作用的细胞因子的不同,分为不同类型:①抗肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)生物制剂(包括抗TNF-α受体抗体,可溶性抗TNF-α融合蛋白);②白细胞介素-1(interleukin-1,IL-1)阻断剂anakinra;③白细胞介素-6(interleukin-6,IL-6)阻断剂:抗IL-6受体单克隆抗体(托珠单抗);④T细胞共刺激信号阻滞剂(阿巴西普);⑤抗CD20单克隆抗体(利妥昔单抗);⑥可溶性B细胞刺激因子(Blys)单克隆抗体(贝里木单抗).其中TNF-α抑制剂在风湿病领域使用最广泛,本文将重点阐述.
作者 陈小奇 Chen Xiaoqi
出处 《医学新知》 CAS 2019年第5期537-540,共4页 New Medicine
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