成人支气管哮喘患者的血脂水平特点及与呼气一氧化氮关系的研究

Characteristics of blood lipid levels and correlation with fractional exhaled nitric oxide in adult patients with bronchial asthma

目的分析成人支气管哮喘患者的血脂水平分布特点,并探讨与外周血嗜酸性粒细胞百分比(EOS%)、呼气一氧化氮(FeNO)、第一秒用力呼气量(FEV 1)的关系。方法收集2016年10月至2019年4月就诊于甘肃省人民医院呼吸与危重症医学科支气管哮喘患者144例,轻中度103例,重度41例,其中男性72例,女性72例,收集患者入院第二日空腹血脂水平(TG、TC、HDL-C、LDL-C),以及EOS%、FeNO、FEV 1等资料。比较不同程度哮喘患者各指标差异;分别比较不同性别、不同EOS%患者的TG、HDL-C、LDL-C、TC水平;采用Spearman分析血脂水平与EOS%、FeNO、FEV 1的相关性。结果轻中度与重度哮喘患者HDL-C、LDL-C、FeNO、FEV 1差异有统计学意义(P<0.05),TG、TC、EOS%差异无统计学意义(P>0.05);哮喘患者男性与女性比较,HDL-C、TC、FeNO、FEV 1差异有统计学意义(P<0.05),TG、LDL-C、EOS%差异无统计学意义(P>0.05);哮喘患者不同嗜酸性粒细胞百分比比较FeNO有统计学意义(P<0.05),而TG、LDL-C、HDL-C、TC、FEV 1差异无统计学意义(P>0.05)。结论不同程度哮喘患者血脂相关指标不同;哮喘患者HDL-C、TC、FeNO、FEV 1水平存在性别差异;不同嗜酸性粒细胞百分比哮喘患者血脂水平以及FeNO无差异;血脂水平与FeNO、FEV 1及EOS%无相关性。

Objective To analyze the distribution of blood lipid levels in adult patients with bronchial asthma,and to explore the relationship between blood lipid levels and percentage of peripheral blood eosinophils(EOS%),fractional exhaled nitric oxide(FeNO),forced expiratory volume in the first second(FEV 1).Methods From October 2016 to April 2019,144 patients with bronchial asthma in the Department of Respiratory and Critical Care Medicine of Gansu Provincial People s Hospital were enrolled.The mild and moderate were 103 cases and 41 were severe,including 72 males and 72 females.The patients were admitted to the hospital on the second day of fasting lipid levels(TG,TC,HDL-C,LDL-C),as well as EOS%,FeNO,FEV 1.Firstly,those indicators were compared between mild and moderate asthma patients and severe cases.Secondly,the levels of TG,HDL-C,LDL-C and TC in different genders and EOS%were compared.Last,the correlation between serum lipid levels and EOS%,FeNO and FEV 1 was explored by Spearman.Results There were significant differences in HDL-C,LDL-C,FeNO and FEV 1 between mild to moderate cases and severe asthma patients(P<0.05),but there was no significant difference in TG,TC and EOS%(P>0.05).There were significant differences in HDL-C,TC,FeNO and FEV 1 between male and female cases(P<0.05),but there was no significant difference in TG,LDL-C and EOS%(P>0.05).According to different EOS%in asthma patients,only FeNO was statistically significant(P<0.05),while TG,LDL-C,HDL-C,TC and FEV 1 were not statistically significant(P>0.05).Conclusion The mild-moderate and severe bronchial asthma patients have different blood lipid,and males and females of asthma patients have different HDL-C,TC,FeNO and FEV 1.Different EOS%of asthma patients have no difference in blood lipid levels or FeNO,and blood lipid levels have no relationship with FeNO,FEV 1 and EOS%.