尘肺病患者主动脉瓣钙化发生现状及相关危险因素分析

Current status of aortic valve calcification in patients with pneumoconiosis and analysis of related risk factors

目的探讨尘肺病患者主动脉瓣钙化发生现状及相关危险因素。方法选择确诊为尘肺病Ⅰ期的194例患者作为研究对象,根据心脏彩超检查结果将其分为钙化组和未钙化组,另选择同期体检正常的健康人200例作为对照组。观察尘肺病患者及健康人主动脉瓣钙化发生情况;先对两组尘肺病患者性别、年龄、体质指数(BMI)、吸烟史、高血压病史、糖尿病史、心率、血压、空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、极低密度脂蛋白胆固醇(VLDLC)、低密度脂蛋白胆固醇(LDLC)、高密度脂蛋白胆固醇(HDLC)、脂蛋白a[Lp(a)]进行单因素分析,而后以有无主动脉瓣钙化为因变量,对两组尘肺病患者中差异有统计学意义的单因素进行多因素Logistic回归分析。结果194例尘肺病患者中,主动脉瓣钙化发生率为20.10%,200例健康人中,主动脉瓣钙化发生率为12.00%,尘肺病患者主动脉瓣钙化发生率明显高于健康人群(P<0.05);单因素分析结果提示两组尘肺病患者年龄、高血压病史、收缩压、FBG、TC、TG差异有显著性(P<0.05);进一步对差异有统计学意义的单因素进行多因素Logistic回归分析,结果显示年龄(OR=2.296,95%CI 1.448~3.639)、收缩压(OR=3.469,95%CI 1.871~6.433)、TG(OR=3.232,95%CI 1.699~6.146)为尘肺病患者主动脉瓣钙化发生的独立危险因素。结论在尘肺病患者中,主动脉瓣钙化发生率较高,年龄、收缩压、TG为尘肺病患者主动脉瓣钙化发生的独立危险因素,通过对上述指标监测,可为尘肺病患者主动脉瓣钙化发生提供预测价值。

Aim To investigate the occurrence and risk factors of aortic valve calcification in patients with pneumoconiosis.Methods 194 cases with pneumoconiosis were selected as the research objects.According to the results of color Doppler echocardiography,they were divided into calcification group and non-calcification group.Another 200 healthy persons with normal physical examination during the same period were selected as the control group.To observe the occurrence of aortic valve calcification in patients with pneumoconiosis and healthy persons,firstly,sex,age,body mass index(BMI),smoking history,hypertension history,diabetes history,heart rate,blood pressure,fasting blood glucose(FBG),triglyceride(TG),total cholesterol(TC),very low density lipoprotein cholesterol(VLDLC),low density lipoprotein cholesterol(LDLC),high density lipoprotein cholesterol(HDLC),lipoprotein a(Lp(a))were analyzed by single factor analysis between the two groups,and then,with or without aortic valve calcification as dependent variable,multivariate Logistic regression analysis was made on the single factor with statistical significance between the two groups of pneumoconiosis patients.Results Among 194 patients with pneumoconiosis,the incidence of aortic valve calcification was 20.10%.Among 200 healthy people,the incidence of aortic valve calcification was 12.00%.The incidence of aortic valve calcification in pneumoconiosis patients was significantly higher than that in healthy people(P<0.05).There were significant differences in age,history of hypertension,systolic blood pressure,FBG,TC and TG among pneumoconiosis patients(P<0.05).Further Logistic regression analysis showed that age(OR=2.296,95%CI 1.448~3.639),systolic blood pressure(OR=3.469,95%CI 1.871~6.433),and TG(OR=3.232,95%CI 1.699~6.146)were independent risk factors for aortic valve calcification in patients with pneumoconiosis.Conclusion In patients with pneumoconiosis,the incidence of aortic valve calcification is higher,and age,systolic pressure and TG are independent risk factors for aortic valve calcification in patients with pneumoconiosis,and monitoring the above indicators can provide predictive value for the occurrence of aortic valve calcification in patients with pneumoconiosis.