摘要
以三氯氧磷、1,2-二肉豆蔻酰甘油及甘油缩丙酮为原料,通过磷酰化、水解等反应合成1,2-二肉豆蔻酰磷脂酰甘油(DMPG),反应收率为75.8%,其结构经过IR,MS,1H NMR及13C NMR等确证。该合成方法具有操作简单、条件温和、收率高等特点。
DMPG was synthesized by phosphorylation reaction and hydrolysis reaction with phosphorus oxychloride,1,2-ditetradecanoyl glycerol and acetone glycerol as raw materials,and the yield was 75.8%.DMPG was characterized by IR analysis,mass spectrometry,1H NMR and 13C NMR spectroscopy.This process could overcome many scale-up challenges that existed in the methods reported in the literature and provided an easy,mild and high yield route for large scale synthesis of DMPG.
作者
刘霞
苏长会
潘涛
沈宏
黄兆琴
LIU Xia;SU Chang-hui;PAN Tao;SHEN Hong;HANG Zao-qin(College of Environment Science and ecology,Jiangsu Open University,Nanjing 210036,China;School of Chemistry and Life Science,Nanjing University Jinling College,Nanjing 210089,China)
出处
《化学研究与应用》
CAS
CSCD
北大核心
2019年第11期1991-1994,共4页
Chemical Research and Application
基金
江苏省高校自然科学基金项目(16KJB150007)资助
江苏开放大学十三五规划课题项目(17SSW-Z-Y-023)资助
江苏开放大学“纳米功能材料研发及环保应用研究团队”项目(102916101)资助
关键词
三氯氧磷
脂质体
磷脂
合成
phosphorus oxychloride
liposomes
phospholipid
synthesis
