醒脑静联合用药对高血压性脑出血术后患者炎症介质与生存质量的影响

Study on The Effect of Xingnaojing Combined with Other Drugs on Inflammatory Mediators and Quality of Life in Patients with Hypertensive Cerebral Hemorrhage after Operation

目的:研究醒脑静联合用药对高血压性脑出血(HCH)患者术后炎症介质与生存质量的影响。方法:回顾性分析2016年2月-2018年3月在本院就诊的163例HCH患者的临床资料。根据用药方案分为联合组(n=82,采用醒脑静联合依达拉奉注射液方案)和单一组(n=81,采用依达拉奉注射液方案)。比较两组临床疗效、炎症介质水平(IL-6、TNF-α、MMP-2、MMP-9)、生存质量情况及脑血肿体积。结果:联合组临床总有效率98.78%,明显高于单一组的83.95%(字2=11.414,P<0.05);治疗后,联合组TNF-α、IL-6、MMP-2、MMP-9水平均低于单一组(P<0.05),联合组生存质量明显优于单一组(P<0.05),联合组脑血肿体积小于单一组(P<0.05)。结论:在西医常规治疗的基础上加用醒脑静注射液,能进一步改善HCH患者微创术后的炎症介质水平与生存质量,减少血肿体积,提高临床疗效。

Objective:To study the effect of Xingnaojing combined with other drugs on inflammatory mediators and quality of life in patients with hypertensive cerebral hemorrhage(HCH).Method:The clinical data of 163 HCH patients in our hospital from February 2016 to March 2018 were analyzed retrospectively.According to the drug regimen,the patients were divided into the combined group(n=82,Xingnaojing combined with Edaravone injection)and the single group(n=81,Edaravone injection).The clinical efficacy,inflammatory mediators(IL-6,TNF-α,MMP-2,MMP-9),quality of life and cerebral hematoma volume were compared between the two groups.Result:The total clinical effective rate of the combined group was 98.78%,significantly higher than 83.95%of the single group(字2=11.414,P<0.05).After treatment,the levels of TNF-α,IL-6,MMP-2 and MMP-9 in the combined group were lower than those in the single group(P<0.05),the quality of life in the combined group was significantly better than that in the single group(P<0.05),and the cerebral hematoma volume in the combined group was smaller than that in the single group(P<0.05).Conclusion:On the basis of conventional western medicine treatment,Xingnaojing injection can further improve the level of inflammatory mediators and the quality of life of HCH patients after minimally invasive surgery,reduce the volume of cerebral hematoma,and improve the clinical efficacy.