基于痰浊理论探讨线粒体自噬与动脉粥样硬化相关性

An analysis of the correlation between mitophagy and atherosclerosis based on the Tanzhuo theory

动脉粥样硬化(Atherosclerosis,AS)是多种心脑血管疾病发生的基础,我国在AS基础与临床方面取得了理想的成果,但在AS病因学的研究还有待进一步提高。研究显示,氧化应激反应与细胞凋亡能够促进动脉粥样硬化发生与发展,线粒体功能障碍可一定程度加重机体氧化应激反应及细胞凋亡速度,这对AS病变有一定影响,从而可调控AS性心血管疾病。线粒体自噬是经对损伤线粒体的自身消化维持细胞稳态,并促进细胞生存,还可以调节凋亡、坏死、衰老功能来决定细胞最终的命运,在急性缺血性心血管疾病中线粒体自噬的作用显著。中医学认为动脉粥样硬化的病理变化属本虚标实、虚实夹杂,和痰浊内阻相关性较大。受损线粒体产生有害物质及线粒体的凋亡在中医可定义为“内生痰浊”范畴,而这种清除损伤线粒体及受损的细胞器的线粒体自噬恰如我们中医祛痰的治法。本文就从痰浊理论探讨线粒体与动脉粥样硬化相关性进行分析,挖掘中医药防治AS的潜在可能具有非常大的研究潜力和应用价值。

Atherosclerosis is the causes of a variety of cardiovascular and cerebrovascular diseases.At present,there were achieved ideal results in China in the basic and clinical research of AS,but it is still shortcomings in the study of the etiology of AS.Studies have shown that oxidative stress and apoptosis can promote the occurrence and development of atherosclerosis.Mitochondrial dysfunction can aggravate oxidative stress and apoptosis rate,eventually leads to AS-related cardiovascular disease.Mitochondrial autophagy can promote cell survival and regulate cell apoptosis,necrosis and aging;in acute ischemic cardiovascular disease,the role of mitochondrial autophagy is significant.In TCM,the pathological cause of atherosclerosis is Benxu Biaoshi(本虚标实)and Xushi Jiaza(虚实夹杂),which is highly correlated with Tanzhuo Neizu(痰浊内阻).In this article,based on the Tanzhuo theory(痰浊理论),the correlation between mitochondria and atherosclerosis was analyzed.TCM on AS has clinical research and application value.