基因转录爆发的信号转导机制

Signal transduction by transcriptional bursting

随着单分子检测技术水平的提高,学术界发现了与传统认知大相径庭的转录现象———转录爆发。基因转录不是连续平稳且波动较小的过程,而是表现出发生时间极不规律、信使RNA产量波动极大的特征。转录爆发本质上是编码和传递调控信号的方式。本文综述了转录爆发现象、转录爆发的两态模型、转录爆发信号转导机制以及其重要的生物学意义。最后,指出了该领域亟待解决的问题。

With the improvement of single molecule detection technology,a new phenomenon termed as“transcriptional bursting”has emerged in recent years.Transcription is intermittent with large fluctuations in the amount of messenger RNA rather than a continuous stable process with small fluctuations.Transcriptional bursting is essentially a way of encoding and transmitting regulatory signals.This paper reviews the phenomenon of transcriptional bursting,the two state model of transcriptional bursting,the possible mechanisms of signal transfer,and the biological significance of transcriptional bursting.The urgent issues to be addressed in this field have been summarized in discussion.