临床药师参与1例侵袭性肺曲霉病个体化治疗分析

Participation of the Clinical Pharmacist in the Individual Treatment of a Patient with Invasive Pulmonary Aspergillosis

目的探讨临床药师对侵袭性肺曲霉病的药学服务方法。方法以1例侵袭性肺曲霉病患者的诊治过程为基础,从伏立康唑的血药浓度监测、CYP2C19代谢酶的基因多态性、药品不良反应等方面讨论临床药师对侵袭性肺曲霉病患者的药学服务。结果临床药师参与评估患者状况,积极给予药学服务,取得较好疗效。结论临床药师应发挥个体化精准用药干预作用,协助医师制订合理的抗真菌治疗方案,促进抗真菌药物的合理应用。

Objective To investigate the way to develop pharmaceutical care for a patient with invasive pulmonary aspergillosis.Methods Based on the diagnosis and treatment of a patient with invasive pulmonary aspergillosis,the pharmaceutical care of the clinical pharmacist for a patient with invasive pulmonary aspergillosis was investigated from the aspects of the blood concentration monitoring of voriconazole,gene polymorphism of CYP2 C19 metabolizing enzyme and adverse drug reactions.Results The clinical pharmacist participated in the evaluation of the patient’s condition and actively gave pharmaceutical care,which had good efficacy.Conclusion The clinical pharmacist can play an individualized and precise role in the drug intervention and assist physicians to formulate rational antifungal regimen,which can promote clinical rational application of antifungal drugs.