乳癖散结胶囊联合小剂量他莫昔芬片治疗对乳腺增生患者血清雌、孕激素的影响及疗效分析

Effect of Rupi Sanjie Capsule Combined with Low-dose Tamoxifen Tablet on Serum Estrogen and Progesterone in Patients with Hyperplasia of Mammary Gland and Its Curative Effect Analysis

目的讨论乳癖散结胶囊联合小剂量枸橼酸他莫昔芬片治疗对乳腺增生患者血清雌、孕激素的影响及疗效。方法方便选择2018年1—6月至该院就诊并诊断为乳腺增生女性患者94例,将所有患者随机分成两组,每组47例;对照组患者接受乳癖散结胶囊治疗,观察组患者接受乳癖散结胶囊联合小剂量枸橼酸他莫昔芬片治疗;连续用药2个月,比较两组患者临床疗效,血清雌、孕激素变化[血清雌二醇(E2)、黄体生成素(LH)、孕酮(P)]。结果治疗后,观察组患者临床总有效率(95.74%)明显高于对照组(82.98%),差异有统计学意义(χ^2=4.029,P<0.05);两组患者E2水平均较治疗前降低,差异有统计学意义(P<0.05),LH、P水平均较治疗前升高,差异有统计学意义(P<0.05);观察组E2水平明显低于对照组,LH、P水平明显高于对照组,差异有统计学意义(t(E2)=17.057、t(LH)=12.929、t(P)=21.503,P<0.05)。结论乳癖散结胶囊联合小剂量枸橼酸他莫昔芬片治疗乳腺增生的疗效显著,安全性较高,且能有效改善患者雌、孕激素水平,对女性身体健康的意义重大,在临床上具有较高的应用价值。

Objective To discuss the effect and efficacy of Rupi Sanjie Capsule combined with low-dose tamoxifen citrate tablets on serum estrogen and progesterone in patients with breast hyperplasia.Methods A total of 94 female patients with breast hyperplasia who were diagnosed in the hospital from January to June 2018 were conveniently selected into the study.All patients were randomLy divided into two groups,47 in each group.The control group received chylomicron capsule treatment.Patients in the observation group received chylorrhea capsules combined with low-dose tamoxifen citrate tablets;continuous treatment for 2 months,comparing the clinical efficacy of the two groups of patients,serum estrogen and progesterone changes[serum estradiol(E2),corpus luteum Producin(LH),progesterone(P)].Results After treatment,the total clinical effective rate(95.74%)of the observation group was significantly higher than that of the control group(82.98%),the difference was statistically significant(χ^2=4.029,P<0.05).The E2 level of the two groups was lower than that before treatment,the difference was statistically significant(P<0.05),LH,P levels were higher than before treatment,the difference was statistically significant(P<0.05);E2 level in observation group was significantly lower than that in control group,LH and P levels were significantly higher than control group,the difference was statistically significant(t(E2)=17.057,t(LH)=12.929,t(P)=21.503,P<0.05).Conclusion Rupi Sanjie Capsule combined with low-dose tamoxifen citrate in the treatment of breast hyperplasia has a significant effect,high safety,and can effectively improve the levels of estrogen and progesterone in patients,which is of great significance to women's health.It has a high application value.