大剂量盐酸氨溴索联合无创通气治疗成人呼吸窘迫综合征的效果观察

Effects of large dose Ambroxol hydrochloride combined with noninvasive ventilation on adult respiratory distress syndrome

目的:观察大剂量盐酸氨溴索联合无创通气治疗成人呼吸窘迫综合征的效果。方法:选取80例成人呼吸窘迫综合征患者作为研究对象,按照随机数字表法将其分为观察组和对照组各40例。两组入院后均实施基础治疗,对照组在此基础上给予无创通气治疗,观察组在对照组的基础上联合大剂量盐酸氨溴索治疗,比较两组治疗效果、血气指标、炎症因子水平及不良反应发生率。结果:观察组的治疗总有效率为95.0%,明显高于对照组的72.5%,差异有统计学意义(P<0.05);治疗后观察组动脉血二氧化碳分压(PaCO2)明显低于对照组,动脉血氧分压(PaO2)明显高于对照组,差异有统计学意义(P<0.05);两组pH值比较差异无统计学意义(P>0.05);治疗后观察组白细胞介素-6、白细胞介素-1β、肿瘤坏死因子-α水平均明显低于对照组,差异均有统计学意义(P<0.05);观察组并发症发生率为5.0%,明显低于对照组的27.5%,差异有统计学意义(P<0.05)。结论:与单用无创通气治疗相比,无创通气联合大剂量盐酸氨溴索治疗成人呼吸窘迫综合征的效果更显著,可明显提高临床疗效,改善患者的血气分析指标和炎性因子水平,降低并发症发生率。

Objective: To investigate effects of noninvasive ventilation combined with large dose Ambroxol hydrochloride in treatment of adult respiratory distress syndrome. Methods: 80 patients with adult respiratory distress syndrome were selected as the study subjects, and they were divided into observation group(n=40) and control group(n=40) according to the random number table method. The two groups were given the basic treatment after admission. Besides, the control group was given noninvasive ventilation, while the observation group used large dose Ambroxol hydrochloride on the basis of that of the control group. The therapeutic effects, blood gas indexes, inflammatory factor levels and incidence of adverse reactions were compared between the two groups. Results: The total effective rate of the observation group was 95.0%, which was significantly higher than that of the control group(72.5%), and the difference was statistically significant(P<0.05). After the treatment, the arterial partial pressure of carbon dioxide(PaCO2) was significantly lower than that of the control group, the arterial partial pressure of oxygen(PaO2) was significantly higher than that of the control group, and the differences were statistically significant(P<0.05). There was no significant difference in pH between the two groups(P>0.05). After the treatment, the levels of interleukin-6, interleukin-1β and tumor necrosis factor-α were significantly lower in the observation group than in the control group, and the differences were statistically significant(P<0.05). The incidence of complication in the observation group was 5.0%, which was significantly lower than that in the control group(27.5%), and the difference was statistically significant(P<0.05). Conclusions: Compared with single noninvasive ventilation, noninvasive ventilation combined with large dose Ambroxol hydrochloride is more effective in the treatment of adult respiratory distress syndrome. It can significantly improve the clinical efficacy, improve the blood gas analysis indicators and inflammatory factor levels, and reduce the complication rate.