多索茶碱联合吸入用布地奈德混悬液治疗小儿支气管哮喘的效果观察

Effects of Doxofylline combined with Budesonide suspension for inhalation on children with bronchial asthma

目的:观察多索茶碱联合吸入用布地奈德混悬液治疗小儿支气管哮喘的效果。方法:选取74例支气管哮喘患儿作为研究对象,采用随机数字表法将其分为对照组和观察组各37例。两组均给予常规心电图监护、止咳、平喘、抗感染等基础治疗,对照组给予布地奈德混悬液吸入治疗,观察组在对照组的基础上联合多索茶碱注射液治疗。比较两组临床疗效、治疗前后血清炎性因子[白细胞介素-17(IL-17)、肿瘤坏死因子(TNF-α)、基质金属蛋白酶-9(MMP-9)]水平、免疫功能指标(CD3^+、CD4^+、CD8^+、CD4^+/CD8^+)水平及不良反应发生率。结果:观察组治疗总有效率为94.59%,高于对照组75.68%,差异有统计学意义(P<0.05);治疗前两组血清IL-17、TNF-α及MMP-9水平比较,差异无统计学意义(P>0.05),治疗后两组IL-17、TNF-α及MMP-9水平均明显低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05);治疗前两组CD3^+、CD4^+、CD4^+/CD8^+、CD8^+水平比较,差异无统计学意义(P>0.05),治疗后观察组CD4^+/CD8^+和CD3^+、CD4^+水平明显低于对照组,CD8^+水平明显高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:与单用布地奈德混悬液相比,多索茶碱注射液联合布地奈德混悬液治疗小儿支气管哮喘的效果更显著,可明显提高临床疗效,减轻炎症反应,调节免疫功能,且安全性强。

Objective:To investigate effects of Doxofylline combined with Budesonide suspension for inhalation on children with bronchial asthma.Methods:74 children with bronchial asthma were selected as the study subjects,and they were divided into control group(n=37)and observation group(n=37)by using the random number table method.Both groups were given basic treatments such as conventional ECG monitoring,cough relieving,antiasthma,and anti-infection.Besides,the control group was given Budesonide suspension for inhalation,while the observation group was treated with Doxofylline injection on the basis of that of the control group.The clinical effi cacy,the serum infl ammatory factor[interleukin-17(IL-17),tumor necrosis factor(TNF-α),matrix metalloproteinase-9(MMP-9)]levels before and after the treatment,the immune function indicator(CD3^+,CD4^+,CD8^+,CD4^+/CD8^+)levels and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 94.59%,which was higher than that of the control group(75.68%),and the difference was statistically signifi cant(P<0.05).There were no signifi cant differences in the serum IL-17,TNF-αand MMP-9 levels between the two groups before the treatment(P>0.05).However,after the treatment,the levels of IL-17,TNF-αand MMP-9 in the two groups were signifi cantly lower than those before the treatment,those of the observation group were lower than those of the control group,and the differences were statistically signifi cant(P<0.05).There were no significant differences in the CD3^+,CD4^+,CD4^+/CD8^+,and CD8^+levels between the two groups before the treatment(P>0.05).However,after the treatment,the levels of CD4^+/CD8^+,CD3^+and CD4^+in the observation group were signifi cantly lower than those in the control group,the level of CD8^+was signifi cantly higher than that in the control group,and the differences were statistically signifi cant(P<0.05).There was no signifi cant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Compared with single Budesonide suspension for inhalation,Doxofylline injection combined with Budesonide suspension for inhalation is more effective in the treatment of the children with bronchial asthma.It can signifi cantly improve the clinical effi cacy,reduce the infl ammatory reactions,and regulate the immune function with high safety.