不同剂量阿托伐他汀治疗脑梗塞颈动脉粥样硬化斑块的疗效分析

Therapeutic Effect of Different Doses of Atorvastatin on Carotid Atherosclerotic Plaque in Patients with Cerebral Infarction

目的了解不同剂量阿托伐他汀治疗脑梗塞颈动脉粥样硬化斑块的临床疗效。方法选取2016年11月-2017年11月在该院接受治疗的脑梗塞颈动脉粥样硬化斑块患者共计72例作为该次研究对象,将上述患者随机分为两组,分别使用小剂量阿托伐他汀和大剂量阿托伐他汀进行治疗,对比其临床治疗效果。结果大剂量治疗组患者治疗后血脂水平中TC(3.65±0.42)mmol/L、TG(1.27±0.31)mmol/L、HDL(2.35±0.38)mmol/L、LDL(1.24±0.46)mmol/L,颈动脉粥样硬化斑块面积(20.43±8.36)mm^2;小剂量治疗组患者治疗后血脂水平中TC(4.23±0.74)mmol/L、TG(1.43±0.75)mmol/L、HDL(2.29±0.48)mmol/L、LDL(2.48±0.52)mmol/L,颈动脉粥样硬化斑块面积(24.31±8.74)mm2。大剂量治疗组患者不良反应率8.33%;小剂量治疗组患者不良反应率5.55%。大剂量阿托伐他汀治疗组患者的血脂水平以及颈动脉粥样硬化面积改善情况优于小剂量治疗组,差异有统计学意义(t=19.210、19.470、19.840、18.930、19.570,P<0.05);两组患者治疗期间的不良反应情况基本相似,差异无统计学意义(χ^2=3.275,P>0.05)。结论选择阿托伐他汀治疗脑梗塞颈动脉粥样硬化斑块能够有效改善患者的相关症状,并且使用大剂量阿托伐他汀能够适当提高治疗效果,治疗中可根据实际情况对用药剂量进行适当调整,促进患者病情改善。

Objective To understand the clinical efficacy of different doses of atorvastatin in the treatment of carotid atherosclerotic plaque in cerebral infarction.Methods A total of 72 patients with cerebral infarction carotid atherosclerotic plaque who were treated in the hospital from November 2016 to November 2017 were enrolled.The patients were randomly divided into two groups,using small doses atorvastatin and high-dose atorvastatin were compared to compare their clinical outcomes.Results In the high-dose treatment group,TC(3.65±0.42)mmol/L,TG(1.27±0.31)mmol/L,HDL(2.35±0.38)mmol/L,LDL(1.24±0.46)mmol/L,carotid atherosclerotic plaque area(20.43±8.36)mm^2;low-dose treatment group TC(4.23±0.74)mmol/L,TG(1.43±0.75)mmol/L,HDL(2.29±0.48)mmol/L,LDL(2.48±0.52)mmol/L,carotid atherosclerotic plaque area(24.31±8.74)mm2.The adverse reaction rate was 8.33%in the high-dose group and 5.55%in the low-dose group.The improvement of blood lipid level and carotid atherosclerotic area in the high-dose atorvastatin group was better than that in the low-dose group,and the difference was statistically significant(t=19.210,19.470,19.840,18.930,19.570,P<0.05).The adverse reactions during the treatment of the two groups were basically similar,and the difference was not statistically significant(χ^2=3.275,P>0.05).Conclusion The choice of atorvastatin for the treatment of cerebral infarction with carotid atherosclerotic plaque can effectively improve the patient’s related symptoms,and the use of high-dose atorvastatin can improve the treatment effect properly,the treatment can be adjusted according to the actual situation to improve the patient’s condition.