复方甘草酸苷治疗慢性乙型肝炎的临床疗效分析

Clinical Efficacy of Compound Glycyrrhizin in the Treatment of Chronic Hepatitis B

目的探讨在慢性乙型肝炎患者中复方甘草酸苷的治疗效果。方法此次抽选2017年1月-2019年1月在该院医治的慢性乙型肝炎患者(60例)做研究,随机分为乙组(30例)、甲组(30例)。两组均常规治疗,乙组加甘草酸二铵治疗,甲组加复方甘草酸苷治疗,总结两组的治疗效果、乙肝病毒基因阴转情况、乙型肝炎e抗原转阴情况、不良反应、肝功能。结果甲组治疗的总有效率(96.67%)高于乙组(80.00%),差异有统计学意义(χ^2=4.043,P=0.044)。甲组的乙肝病毒基因转阴率(73.33%)高于乙组(46.67%),差异有统计学意义(χ^2=4.444,P=0.035)。甲组的乙型肝炎e抗原转阴率(40.00%)高于乙组(13.33%),差异有统计学意义(χ^2=5.455,P=0.020)。甲组不良反应的总发生率(6.67%)低于乙组(26.67%),差异有统计学意义(χ^2=4.320,P=0.038)。甲组的总胆红素(58.11±4.62)μmol/L低于乙组(87.52±5.33)μmol/L,差异有统计学意义(t=22.837,P=0.000)。甲组的白蛋白(36.33±5.41)g/L高于乙组(30.21±3.58)g/L,差异有统计学意义(t=5.167,P=0.000)。甲组的丙氨酸氨基转移酶(62.05±3.14)U/L低于乙组(87.51±8.02)U/L,差异有统计学意义(t=16.191,P=0.000)。甲组的谷草转氨酶(20.22±3.58)U/L低于乙组(31.90±4.22)U/L,差异有统计学意义(t=11.560,P=0.000)。结论在慢性乙型肝炎患者中,复方甘草酸苷的疗效确切,安全性高、治疗有效率高,提高乙肝病毒基因、乙型肝炎e抗原的转阴率,并显著改善肝功能。

Objective To investigate the therapeutic effect of compound glycyrrhizin in patients with chronic hepatitis B.Methods This study was conducted on patients with chronic hepatitis B(60 cases)who were treated in the hospital from January 2017 to September 2019.They were randomly divided into group B(30 cases)and group A(30 cases).Both groups were treated routinely.Group B was treated with diammonium glycyrrhizinate.Group A was treated with compound glycyrrhizin.The therapeutic effects of the two groups,the negative conversion of hepatitis B virus gene,the negative conversion of hepatitis B e antigen,adverse reactions,liver function.Results The total effective rate of treatment in group A(96.67%)was higher than that in group B(80.00%),and the difference was statistically significant(χ^2=4.043,P=0.044).The conversion rate of hepatitis B virus gene in group A(73.33%)was higher than that in group B(46.67%),and the difference was statistically significant(χ^2=4.444,P=0.035).The conversion rate of hepatitis B e antigen in group A(40.00%)was higher than that in group B(13.33%),and the difference was statistically significant(χ^2=5.455,P=0.020).The overall incidence of adverse reactions in group A(6.67%)was lower than that in group B(26.67%),and the difference was statistically significant(χ^2=4.320,P=0.038).The total bilirubin(58.11±4.62)μmol/L in group A was lower than that in group B(87.52±5.33)μmol/L,and the difference was statistically significant(t=22.837,P=0.000).The albumin height of group A was(36.33±5.41)g/L in group B(30.21±3.58)g/L,and the difference was statistically significant(t=5.167,P=0.000).The alanine aminotransferase(62.05±3.14)U/L of group A was lower than that of group B(87.51±8.02)U/L,and the difference was significant(t=16.191,P=0.000).The U/L of the aspartate aminotransferase(20.22±3.58)in group A was lower than that in group B(31.90±4.22)U/L,and the difference was statistically significant(t=11.560,P=0.000).Conclusion In patients with chronic hepatitis B,the compound glycyrrhizin has exact curative effect,high safety and high therapeutic efficiency,and improves the conversion rate of hepatitis B virus gene and hepatitis B e antigen,and significantly improves liver function.