电子烟与复合型电子烟产品的化学成分对比分析

Comparison of chemical components between e-cigarettes and hybrid e-cigarettes

为比较分析2种复合型电子烟样品(Hy-1、Hy-2)和1种电子烟(Ec-3),以其主要成分(甘油、丙二醇和烟碱)及烟草特有亚硝胺(TSNAs)为分析指标,对烟液、烟草段及气溶胶样品分别进行了气相色谱分析和液相色谱质谱联用分析。结果表明:①对于烟液,均采用甘油、丙二醇作为主要溶剂,其中样品Hy-1不含烟碱,另外2种样品均含烟碱,且标示值与实测值偏差均小于10%;②对于烟草段,Hy-1烟草颗粒中烟碱含量明显高于Hy-2的烟丝,从抽吸前后各成分含量的变化可以看出,Hy-1的烟草颗粒吸附了部分丙二醇,Hy-2的烟草段对甘油、丙二醇及烟碱均有吸附;③对于气溶胶,Hy-1在不加烟草颗粒抽吸时无烟碱释放,加入烟草颗粒后烟碱释放量与Hy-2相近,但Ec-3的烟碱释放量要明显高于复合型样品;④Ec-3的烟液、气溶胶中均未检出TSNAs,2种复合型产品的烟草段均检出4种TSNAs,而雾化产生的气溶胶中仅检出微量NNN。

To compare the chemical components in e-cigarettes(Ec-3) with those in two hybrid e-cigarette products(coded as Hy-1 and Hy-2), the main components(glycerol, propylene glycol and nicotine) and tobacco-specific nitrosamines(TSNAs) were selected as analytes to analyze e-liquids, tobacco segments and aerosol samples with GC and LC-MS/MS methods. The results showed that: 1) For e-liquids, glycerin and propylene glycol were used as main solvents. The Hy-1 sample was nicotine-free in its e-liquid, while the samples of Ec-3 and Hy-2 contained nicotine, and the deviation between the labeled values and the measured nicotine values was less than 10%. 2) For tobacco segments, the nicotine content in Hy-1 was significantly higher than that in Hy-2. The chemical composition of the tobacco segments differed before and after puffing, which indicated that tobacco particles of Hy-1 adsorbed partial propylene glycol and tobacco segments of Hy-2 adsorbed glycerol,propylene glycol and nicotine. 3) For aerosol, no measurable nicotine was released from Hy-1 before adding tobacco particles, while the nicotine release was closed to that from Hy-2 after adding tobacco particles. The release of nicotine from Ec-3 was significantly higher than that from the hybrid samples. 4) TSNAs were not detected in the e-liquid and aerosol of Ec-3, and were detected in the tobacco segments of Hy-1 and Hy-2, but only trace NNN was detected in their aerosols.