肺动脉瓣曲线a波深度变化与肺动脉高压之间的相关关系研究

Correlation between the a-wave depth of pulmonary valve curve and pulmonary hypertension

目的探讨肺动脉高压患者肺动脉瓣M型曲线a波深度变化与肺动脉高压之间的相关性。方法选取50例肺动脉高压患者(肺高压组)及50例健康成人(正常对照组),均行二维及M型超声心动图检查,测量三尖瓣最大反流压差(TRPG)和肺动脉瓣口血流频谱上升支加速时间(ACTpv),分析肺动脉瓣M型曲线a波深度与TRPG、ACTpv之间的相关性。结果肺高压组患者肺动脉瓣M型频谱a波深度明显低于正常对照组,ACTpv亦低于正常对照组[(70.04±11.28)ms vs.(128.37±19.64)ms],TRPG高于正常对照组[(41.63±4.59)mm Hg vs.(17.74±3.58)mm Hg],差异均有统计学意义(均P<0.05)。肺动脉瓣M型曲线a波深度与ACTpv呈正相关(r=0.401,P<0.05),与TRPG呈负相关(r=-0.547,P<0.05)。结论肺动脉高压患者肺动脉瓣M型曲线a波深度与ACTpv、TRPG有一定相关性,通过测量肺动脉瓣M型频谱a波深度可以评估肺动脉压力。

Objective To analyze the correlation between the a-wave depth of pulmonary valve curve and pulmonary hypertension.Methods Fifty patients with pulmonary hypertension(pulmonary hypertension group)and 50 healthy subjects(normal control group)were selected. They were umderwent two-dimensional ultrasound and M-mode echocardiography,the tricuspid regurgitation pressure gradient(TRPG) and acceleration time of ascending branch of pulmonary valve orifice blood flow spectrum(ACTpv)were measured.The correlation between the a-wave depth of M-mode spectrum of pulmonary valve and TRPG,ACTpv were analyzed.Results The a-wave depth of M-mode spectrum of pulmonary valve and ACTpv in the pulmonary hypertension group were significantly lower than those in the normal control group[(70.04±11.28)ms vs.(128.37±19.64)ms],TRPG was higher than that in normal control group[(41.63±4.59)mm Hg vs.(17.74±3.58)mm Hg],there were significant differences(all P<0.05). The a-wave depth of pulmonary valve M-shaped curve was positively correlated with ACTpv and negatively correlated with TRPG(r=0.401,-0.547,both P<0.05). Conclusion The a-wave depth of M-mode spectrum of pulmonary valve is correlated with ACTpv and TRPG,it can be used as another evidence to judge the degree of pulmonary hypertension.