2型糖尿病合并甲亢患者骨密度及骨代谢的特点分析

Characteristics of Bone Mineral Density and Bone Metabolism in Patients with Type 2 Diabetes Complicated with Hyperthyroidism

目的分析2型糖尿病合并甲亢患者骨密度(BMD)及骨代谢的特点。方法2018年1月—2019年1月,选择68例2型糖尿病合并甲亢患者作为观察组,另选同期68例甲状腺功能正常的2型糖尿病患者作为对照组;比较两组不同部位BMD、骨代谢指标及血糖控制效果。结果观察组不同部位BMD均明显小于对照组,血清25(OH)D、BGP、TPⅠNP水平均明显低于对照组,β-CTX水平均明显高于对照组,差异有统计学意义(P<0.05);观察组治疗后FBG、2 hPBG、HbA1c水平均明显低于对照组,差异有统计学意义(P<0.05)。结论2型糖尿病患者合并甲亢可进一步增加骨吸收,降低骨形成,影响血糖控制效果。

Objective To analyze the characteristics of bone mineral density(BMD)and bone metabolism in patients with type 2 diabetes mellitus complicated with hyperthyroidism.Methods 68 patients with type 2 diabetes mellitus complicated with hyperthyroidism from January 2018 to January 2019 were selected as the observation group.68 patients with type 2 diabetes mellitus with normal thyroid function were selected as the control group.BMD,bone metabolism index and blood glucose control effect were compared between different groups.Results The BMD of different parts of the observation group was significantly lower than that of the control group.The serum levels of 25(OH)D,BGP and TPINP were significantly lower than those of the control group,and theβ-CTX level was significantly higher than that of the control group.The difference was statistically significant(P<0.05);FBG,2 hPBG,HbA1c levels in the observation group were significantly lower than the control group,the difference was statistically significant(P<0.05).Conclusion Patients with type 2 diabetes with hyperthyroidism can further increase bone resorption,reduce bone formation and affect blood glucose control.