新型水溶性AgBiS2纳米颗粒在光热、放射治疗与活体成像中的应用

Applications of water-soluble AgBiS2 nanoparticles in photothermal/radiotherapy and in vivo imaging

贵金属纳米材料与高Z元素纳米材料都是生物无机材料领域的重要研究对象,而同时包含两者的三元硫化物AgBiS2纳米颗粒是首次被用于生物医疗领域。制备一种经PEG修饰的水溶性AgBiS2纳米颗粒,并通过体外测试、细胞实验以及小鼠活体成像,证明该材料具有良好的光热杀伤、放疗增敏产生ROS与DNA损伤以及光声与CT成像能力。

Noble metal and high Z number nanomaterials are both popular stuff in the bioinorganic materials field, while the biomedical application of ternary sulfides AgBiS2 nanomaterial containing the two nanomaterials is reported for the first time. We synthesized a water-soluble AgBiS2 nanoparticle with PEG modification, and carried out a set of in vitro, intracellular, and mice imaging experiments that revealed its low cytotoxicity, photothermal lethality toward cancer cells, ability to cause DNA lesions by generating ROS under X-ray radiation which suppresses the reproduction of cancer cells, and good performance as photoacoustic and CT contrast agent.