家庭医生社区干预联合双歧杆菌三联活菌胶囊治疗2型糖尿病的效果评价

Effect evaluation on family doctor community intervention combined with Bifidobacterium triple viable capsule for type 2 diabetes mellitus

【目的】评价家庭医生社区干预联合双歧杆菌三联活菌胶囊对2型糖尿病患者的治疗效果。【方法】选取上海市曲阳路街道社区2型糖尿病患者100例随机分为研究组与对照组各50例。在实施强化教育管理、优化生活方式、定期监测血糖、指导降糖药物使用等家庭医生社区综合干预方案基础上,研究组给予双歧杆菌三联活菌胶囊治疗;对照组给予安慰剂。疗程均为3个月。比较社区干预前后,两组治疗前、治疗3个月后及停药3个月后患者空腹血糖(FBG)和糖化血红蛋白(HbA1c)水平的变化情况。【结果】家庭医生社区综合干预后患者FBG(6.95±1.54)mmol/L与HbA1c(6.92%±0.90%)水平均显著好转(P<0.01);菌群调节治疗后FBG(6.59±1.62 mmol/L)与HbA1c(6.75%±0.95%)水平进一步好转(P<0.05),治疗有效率明显优于对照组(P<0.05),停药后FBG(7.12±1.45)mmol/L与HbA1c(6.94%±1.06%)水平回升(P<0.05);对照组治疗前后及停药后FBG与HbA1c差异无统计学意义(P>0.05)。【结论】家庭医生社区干预模式对2型糖尿病患者实施管理和治疗行之有效,联合双歧杆菌三联活菌胶囊治疗2型糖尿病效果明确。

[Objective]To evaluate the therapeutic effect of family doctor community intervention combined with Bifidobacterium triple viable capsule for type 2 diabetes mellitus.[Methods]A total of 100 patients with type 2 diabetes mellitus(T2DM)from Quyang Road Street Community were selected and randomly divided into study group and control group.On the basis of implementing a comprehensive intervention program for family doctors such as intensive education management,lifestyle optimization,regular monitoring of blood sugar and hypoglycemic drugs,the patients(n=50)in the study group were treated with Bifidobacterium triple live capsules,and the patients(n=50)in the control group were given placebo.The course of treatment was 3 months.Before and after community intervention,the changes of fasting blood glucose and glycosylated hemoglobin were compared in the two groups before treatment,3 months after treatment and 3 months after suspension of the drug.[Results]After comprehensive intervention by family doctors,FBG(6.95±1.54)mmol/L and HbA1c(6.92%±0.90%)levels of patients in the two groups obviously declined as compared with before(P<0.01).The levels of FBG(6.59±1.62)mmol/L and HbA1c(6.75%±0.95%)further declined after the adjustment of patients′intestinal flora(P<0.05),and the treatment efficiency was significantly better than that of the control group(P<0.05),FBG(7.12±1.45)mmol/L and HbA1c(6.94%±1.06%)levels rebounded after withdrawal(P<0.05).Meanwhile,in the control group,there was no statistical difference in FBG and HbA1c before and after treatment,and after withdrawal(P>0.05).[Conclusion]The family doctor community intervention model proves to be effective in the management and treatment of community T2DM patients,and combination with Bifidobacterium triple viable capsule has significant curative effect on patients with T2DM.