感染患者的维生素D水平与CRP关系

Relationship between vitamin D and CRP in infected patients

目的研究感染患者的维生素D与C反应蛋白(CRP)的关系。方法检测急诊病房收治的308例患者的血常规、血生化及血清25羟维生素D[25(OH)D]等指标;根据病情将患者分为感染组和非感染组,比较两组患者的相关指标,并对感染组患者的血清25(OH)D与CRP水平进行相关性研究。结果308例患者中有175例为感染患者,主要为肺部感染。25(OH)D在感染组和非感染组中的水平分别为[13.0(9.0)]μg/L和[15.0(10.0)]μg/L,两者比较存在统计学差异(P<0.05)。但感染患者血清25(OH)D和CRP水平无明显相关性。不同感染部位的患者也分别进行两者的相关性分析,未发现显著的线性相关性。结论维生素D缺乏与反映炎症强弱的CRP并不相关,对于病情严重程度无提示作用。

Objective To investigate the relationship between vitamin D and C-reactive protein(CRP)in infected patients.Methods The blood routine,blood biochemistry and serum 25-hydroxyvitamin D[25(OH)D]and other indicators of 308 patients admitted to the emergency ward were detected.According to the illness condition,the patients were divided into the infected group and the non-infected group.The related indicators of the two groups were compared,and the correlational study between the serum 25(OH)D level and the CRP level of the infected group was conducted.Results Of the 308 patients,175 patients were infected,mainly with pulmonary infection.The levels of 25(OH)D in the infected and non-infected groups were[13.0(9.0)]μg/L and[15.0(10.0)]μg/L,respectively,with statistical difference(P<0.05).However,there was no significant correlation between the serum 25(OH)D level and the CRP level in the infected patients.The correlation analysis between the patients with different infection sites was also conducted and no significant linear correlation was found.Conclusion Vitamin D deficiency is not related to CRP,the indicator of inflammation degree,and has no indication on the severity of disease.