子痫前期睡眠呼吸暂停低通气综合征患者血清MCP-1、IL-18、LP(a)表达

The expression of serum MCP-1, IL-18 and LP(a) of preeclampsia women with sleep apnea hypopnea syndrome

目的:探讨血清单核趋化蛋白(MCP)1、白介素(IL)18、脂蛋白(LP)a在子痫前期睡眠呼吸暂停低通气综合征(SAHS)患者表达。方法:选择2016年3月-2018年3月本院接诊的子痫前期合并SAHS患者60例(SAHS组)、单纯子痫前期患者50例(子痫前期组)和健康妊娠孕妇50例(对照组),检测各组血清MCP-1、IL-18、LP(a)、睡眠呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSaO 2)表达,分析血清指标在子痫前期合并SAHS患者中的表达意义。结果:SAHS组血清MCP-1、IL-18、LP(a)、AHI高于另外两组,LSaO 2低于另外两组,子痫前期组血清MCP-1、IL-18、LP(a)高于对照组(均P<0.05),AHI、LSaO 2子痫前期组与对照组比较无差异(P>0.05);Pearson相关性分析显示,血清MCP-1、IL-18、LP(a)与AHI、LSaO2均呈正相关(P<0.05);logstic回归分析显示,血清MCP-1、IL-18、LP(a)均是子痫前期合并SAHS发病的危险因素(P<0.05);经ROC曲线分析显示,血清MCP-1诊断子痫前期合并SAHS的敏感度、特异度分别为78.5%、74.1%,血清IL-18分别为80.5%、78.3%,血清LP(a)分别为81.0%、75.3%。结论:血清MCP-1、IL-18、LP(a)参与子痫前期合并SAHS的发生和发展,为临床诊治提供新思路。

Objective:To study the expression of serum monocyte chemoattractant protein(MCP)1,interleukin(IL)18,and lipoprotein(LP)a of preeclampsia women with sleep apnea hypopnea syndrome(SAHS).Methods:From March 2016 to March 2018,60 women with preeclampsia combined with SAHS were selected in group A,50 women with preeclampsia only were selected in group B,and 50 healthy pregnant women were selected in group C.The levels of MCP-1,IL-18 and LP(a),and the values of sleep apnea hypopnea index(AHI)and the value of the lowest oxygen saturation(LSaO 2)of women in three groups were detected,and their significance in group A was analyzed.Results:The serum MCP-1,IL-18,LP(a)levels and AHI value of women in group A were significant higher than those of women in group B and C,but the LSaO 2 value was significant lower(P<0.05).The serum MCP-1,IL-18 and LP(a)of women in group B were significant higher than those of women in group C(P<0.05),but there were no significant difference in values of AHI and LSaO 2 of women between the group B and group C(P>0.05).Pearson correlation analysis showed that there was a positive correlation between the serum levels of MCP-1,IL-18,LP(a)and the values of AHI and LSaO 2(P<0.05).The logistical regression analysis showed that the serum MCP-1,IL-18 and LP(a)levels were the risk factors for preeclampsia complicated with SAHS(P<0.05).The ROC curve analysis showed that the sensitivity of serum MCP-1 level,IL-18 level and LP(a)level for diagnosing preeclampsia combined with SAHS were 78.5%,80.5%and 81.0%,respectively.The specificity of serum MCP-1 level,IL-18 level and LP(a)level for diagnosing preeclampsia combined with SAHS were 74.1%,78.3%,and 75.3%,respectively.Conclusion:The serum MCP-1,IL-18 and LP(a)are involved in the occurrence and development of preeclampsia combined with SAHS,which provides new idea for clinical diagnosis and treatment of preeclampsia combined with SAHS.