探讨FGF23在老年患者冠状动脉介入围术期血清中的变化

Study on changes of serum FGF23 level during perioperative period in elderly patients with coronary arterial intervention

目的通过检测成纤维母细胞生长因子23(FGF23)在老年患者冠状动脉介入围术期血清中的变化,评估其反映老年人群早期肾功能损害价值。方法选择该院2016年6月至2017年3月行冠状动脉介入术的老年患者65例(>60岁),监测冠状动脉介入术前及术后其血清中FGF23、血肌酐(Cr)、尿素氮(BUN)、血尿酸(UA)、血清半胱氨酸蛋白酶抑制剂C(Cys C)等指标的变化,并进行相关性分析,评估FGF23能否反映早期肾功能损害情况。结果患者行冠状动脉介入术后24 h血清中FGF23、Cr、BUN、UA、Cys C水平较术前均升高(P<0.01);术后72 h以上指标下降,与术前差异无统计学意义(P>0.05)。FGF23在血清中的水平与Cr、UA、Cys C水平呈正相关。结论FGF23可作为老年患者造影剂肾病早期监测的新型生物标记物。

Objective To detect the changes of serum fibroblast growth factor 23(FGF23)during perioperative period in the elderly patients with percutaneous coronary intervention(PCI)and to evaluate its value for reflecting early renal function impairment in elderly people.Methods Sixty-five elderly patients(>60 years old)with PCI in this hospital were selected.The changes of serum FGF23,blood creatinine(Cr),urea nitrogen(BUN),blood uric acid(UA),serum cystatin C(Cys C)were monitored before and after PCI.The correlation analysis was conducted and the early renal function impairment situation was evaluated.Results The levels of serum FGF23,Cr,BUN,UA and Cys C level at postoperative 24 h of PCI were elevated compared with those before operation(P<0.01);The above indexes decreased 72 hours after surgery,and the differences were not statistically significant(P>0.05).The serum FGF23 level was significantly correlated with the levels of Cr,UA and Cys C levels.Conclusion FGF23 can serve as a new biological marker of contrast induced nephropathy(CIN)in elderly patient.