血浆可溶性脂蛋白受体相关蛋白1水平与冠心病严重程度的关系

Association between plasma soluble lipoprotein receptor-related protein-1 level with severity of coronary heart disease

目的通过比较不同类型冠心病患者血浆可溶性脂蛋白受体相关蛋白1(sLRP-1)水平,并分析sLRP-1水平与冠状动脉造影结果的相关性,探讨sLRP-1与冠心病临床和冠状动脉病变严重程度的关系。方法250例入选患者根据临床症状及冠脉造影结果分为对照组(50例)、稳定型心绞痛组(42例)、急性冠脉综合征组(158例);200例冠心病患者根据冠状动脉造影结果分为单支病变组(67例)、双支病变组(48例)、三支病变组(56例)及左主干病变组(29例);根据冠状动脉Gensini积分分为低Gensini分值组(66例)、中Gensini分值组(67例)和高Gensini分值组(67例)。sLRP-1(μg/mL)水平呈偏态分布,经取lg转换后呈正态分布,以lg sLRP-1(μg/mL)进行统计分析。结果急性冠脉综合征组血浆lg sLRP-1水平(0.67±0.24)μg/mL高于稳定型心绞痛组(0.42±0.16)μg/mL及对照组(0.27±0.18)μg/mL(P<0.05),而稳定型心绞痛与对照组差异无统计学意义(P>0.05)。单支血管病变组(0.65±0.24)μg/mL、双支血管病变组(0.64±0.23)μg/mL、三支血管病变组(0.56±0.27)μg/mL及左主干病变组(0.59±0.28)μg/mL血浆lg sLRP-1水平差异无统计学意义(P>0.05)。低Gensini分值组(0.60±0.27)μg/mL、中Gensini分值组(0.61±0.24)μg/mL和高Gensini分值组(0.63±0.25)μg/mL血浆lg sLRP-1水平差异亦无统计学意义(P>0.05)。结论血浆sLRP-1水平与冠心病临床严重程度相关,而与冠状动脉病变严重程度无明显相关性。

Objective To analyze the correlation between plasma soluble low-density lipoprotein receptor-related protein-1(sLRP-1)level and coronary arterial angiographic results by comparing the plasma sLRP-1 levels in the patients with different types of coronary heart disease(CHD)and to investigate the association between sLRP-1 with CHD clinic and severity degree of coronary arterial lesions.Methods The selected 250 cases were divided into the control group(n=50),stable angina pectoris group(n=42)and acute coronary syndrome group(n=158)according to the clinical symptoms and coronary arterial angiographic results.Two hundreds cases of CHD were divided into the single-vessel lesion group(n=67),double-vessel lesions group(n=48),triple-vessel lesions group(n=56)and left main coronary artery lesion group(n=29)according to the coronary arterial angiographic results;they were divided into the low Gensini score group(n=66),middle Gensini score group(n=67)and high Gensini score group(n=67)according to the coronary arterial Gensini score.The sLRP-1 levels showed the skewness distribution and demonstrated the normal distribution after lg conversion.Then the statistical analysis was performed by lg sLRP-1(μg/mL).Results The plasma lg sLRP-1 level in the acute coronary syndrome group was(0.67±0.24)μg/mL,which was higher than(0.27±0.18)μg/mL)in the control group and(0.42±0.16)μg/mL in the stable angina pectoris group(P<0.05),but there was no statistically significant difference between the stable angina pectoris group and control group(P>0.05).The plasma lg sLRP-1 levels were(0.65±0.24)μg/mL,(0.64±0.23)μg/mL,(0.56±0.27)μg/mL and(0.59±0.28)μg/mL in the single-vessel lesion group,double-vessel lesions group,triple-vessel lesions group and left main coronary artery lesion group respectively,and the differences had no statistical significance(P>0.05).The plasma lg sLRP-1 levels were(0.60±0.27)μg/mL,(0.61±0.24)μg/mL and(0.63±0.25)μg/mL for the low Gensini score group,middle Gensini score group and high Gensini score group respectively,which had no statistical difference(P>0.05).Conclusion The plasma sLRP-1 level is associated with clinical severity of CHD,but has no obvious association with the severity of coronary arterial lesions.