多囊卵巢综合征患者血清肌肉生长抑素含量与脂代谢、胰岛素抵抗及炎症反应的关系

Relationship of serum myostatin content with lipid metabolism, insulin resistance and inflammatory response in patients with polycystic ovary syndrome

目的:探讨多囊卵巢综合征(PCOS)患者血清肌肉生长抑素(Myostatin)含量与脂代谢、胰岛素抵抗及炎症反应的关系。方法:118例PCOS患者作为PCOS组,同期在本院进行体检的健康育龄期女性100例作为正常对照组。对比两组血清Myostatin含量、脂代谢指标水平、胰岛素抵抗指标水平、炎症介质含量的差异,进一步分析PCOS患者血清Myostatin含量与上述病情相关指标水平的内在联系。结果:PCOS组血清中Myostatin的含量高于正常对照组。PCOS组外周血中脂代谢指标TC、LDL-C、ApoB的水平高于正常对照组,HDL-C、ApoA-Ⅰ的水平低于正常对照组;胰岛素抵抗指标FINS、HOMA-IR的水平高于正常对照组;炎症介质IL-18、MCP-1、CRP的含量高于正常对照组。Pearson检验发现,PCOS患者血清中Myostatin的含量与上述病情相关指标的水平均直接相关。结论:PCOS患者血清中Myostatin含量异常增高,具体含量与患者病情严重程度呈正相关。

Objective:To investigate the relationship of serum myostatin content with lipid metabolism,insulin resistance and inflammatory response in patients with polycystic ovary syndrome(PCOS).Methods:A total of 118 PCOS patients were taken as the PCOS group,and 100 healthy women at child-bearing age who underwent physical examination in our hospital during the same period were taken as the normal control group.The differences in serum myostatin content,lipid metabolism index levels,insulin resistance index levels and inflammatory mediator contents were compared between the two groups,and the internal relationship between serum myostatin content and the above disease-related index levels in PCOS patients was further analyzed.Results:Serum myostatin content,as well as peripheral blood lipid metabolism indexes including TC,LDL-C and ApoB levels in PCOS group were higher than those of normal control group,whereas HDL-C and ApoA-Ⅰlevels were lower than those of normal control group.In addition,insulin resistance indexes including FINS and HOMA-IR levels as well as inflammatory mediators IL-18,MCP-1 and CRP contents were higher than those of normal control group.Pearson test showed that serum myostatin content in PCOS patients was directly correlated with the levels of the above disease-related indexes.Conclusion:Serum myostatin content is abnormally high in PCOS patients,and the specific content is positively correlated with the disease severity.