我国雾化吸入疗法的临床应用现状及用药误区

Clinical Application Status and Medication Mismanagement of Atomization Inhalation Therapy in China

雾化吸入疗法是利用气体射流原理,通过雾化装置使药物形成微小雾滴或颗粒,通过吸入方式进入呼吸道及肺部,沉积于肺泡,达到治疗疾病的目的。由于雾化吸入疗法治疗呼吸系统相关疾病具有起效快、药物用量少、安全性高等特点深受医生和患者的青睐。在我国,由于缺乏雾化专用药物剂型和设备,以及受临床医生医疗经验水平差异的影响,雾化吸入治疗在实际操作中常出现超说明书用药情况,这些经验用药手段在药物稳定性、有效性和安全性方面都缺乏相应的系统评价研究,进而影响到患者的治疗效果和安全。因此,针对我国雾化药物临床使用欠规范情况,有必要就雾化吸入装置选择、临床应用现状及用药误区进行总结和思考。

Atomization inhalation therapy achieves the goal of treatment by inhaling tiny drug droplets or particles, which were transformed through an atomizer using the gas-jet stream principle, into the respiratory tract and lungs to deposit on the alveolar.It has the advantages of fast response, low dosage and high safety in the treatment of respiratory diseases.Therefore, the atomization inhalation therapy is generally favored by both doctors and patients.In China, due to the lack of the special devices for atomization dosage forms and varied levels of clinicians’ experience, atomization inhalation therapy was often involved in off-label drug uses.These empirical medications lacked the corresponding systematic evaluations in terms of drug stability, efficacy and safety, thus affecting the therapeutic effect on patients.This review discusses the choices of atomization devices, current application status and medication mismanagement of atomization inhalation therapy in China.